Psychotherapy for Intermittent Explosive Disorder

NCT00667212 | Completed DMC

• 1 other identifier: 15143A
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to examine the effectiveness two forms of psychotherapy (also known as "talk therapy" ) for individuals with anger and aggression problems. Anger and aggression are everywhere - on the road, in the schools, at little league games, at home, and at work. In this study we are testing usefulness of anger management techniques in reducing symptoms of Intermittent Explosive Disorder (IED) and impulsive, aggressive behavior.

Conditions

Anger; Intermittent Explosive Disorder

Keywords

anger; intermittent; explosive

Outcome Measures

Primary Outcomes (3)

• Change in Overt Aggression Scale - Modified (OASM) Score

  Items are scored on a 5-point scale. Higher scores indicate higher levels of aggression.

  Up to 12 months

• Change in State-Trait Anger Expression Inventory - Trait Anger Scale [STAXI-2]

  Items are scored on a 4-point scale. Higher scores indicate high levels of anger.

  Up to 12 months

• Change in Hostile Automatic Thoughts (HAT) Scale

  Each item is answered on a 5-point Likert scale ranging from 0=not at all to 5=all the time. Higher scores indicate higher frequency of hostile thoughts experienced.

  Up to 12 months

Secondary Outcomes (2)

• Change in Self-Report of Aggression and Social Behavior Measure (SRASBM) Score

  Up to 12 months

• Change in Social Information Processing-Attribution and Emotional Response Questionnaire (SIP-AEQ) Score

  Up to 12 months

Study Arms (2)

2

ACTIVE COMPARATOR

Supportive Psychotherapy

Behavioral: Supportive Psychotherapy

1

ACTIVE COMPARATOR

Cognitive Behavioral Therapy (Cognitive Restructuring, Relaxation, and Coping Skills Training: CRCST)

Behavioral: Cognitive Behavioral Therapy

Interventions

Cognitive Behavioral Therapy BEHAVIORAL

Twelve weekly therapy sessions, approximately one hour each in duration

Also known as: Cognitive Restructuring, Relaxation, and Coping Skills Training

1

Supportive Psychotherapy BEHAVIORAL

Twelve weekly therapy sessions, approximately one hour each in duration

2

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Have problems with anger, temper outbursts, being irritable, getting in trouble at work or at home because of impulsive/aggressive behavior.
• Between the ages of 18 and 55.
• Meet other eligibility requirements as outlined by the research protocol.

You may not qualify if:

• Lifetime diagnosis of psychosis or bipolar disorder
• Current diagnosis of substance dependence or major depressive disorder.
• Current suicidal or homicidal ideation,
• Recent use of selective serotonin reuptake inhibitors (past month) or other psychotropic medication (past two months)
• Recent psychotherapy for aggression (past six months.)

Sponsors & Collaborators

• University of Chicago: lead

Study Sites (1)

University of Chicago

Chicago, Illinois, 60637, United States

Location

MeSH Terms

Conditions

Disruptive, Impulse Control, and Conduct Disorders

Interventions

Cognitive Behavioral Therapy; Cognitive Restructuring

Condition Hierarchy (Ancestors)

Mental Disorders

Intervention Hierarchy (Ancestors)

Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Michael McCloskey, PhD

  University of Chicago

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 24, 2008
• First Posted: April 28, 2008
• Study Start: August 1, 2006
• Primary Completion: December 1, 2010
• Study Completion: December 1, 2010
• Last Updated: August 19, 2024

Record last verified: 2024-08

Locations

US (1)