Multicenter Myocardial Viability Trial
An International, Multicenter Trial Assessing Myocardial Viability With Contrast - Enhanced Magnetic Resonance Imaging
3 other identifiers
observational
235
6 countries
7
Brief Summary
The purpose of this study is to test the hypothesis of whether contrast enhanced Magnetic Resonance Imaging can be used to predict improvement of the wall motion in regions of the heart with abnormal movement following bypass surgery or percutaneous angioplasty in various institutions across three continents.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2003
Longer than P75 for all trials
7 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 11, 2003
CompletedFirst Submitted
Initial submission to the registry
April 16, 2008
CompletedFirst Posted
Study publicly available on registry
April 18, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 14, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
May 15, 2011
CompletedDecember 2, 2020
November 1, 2020
7.4 years
April 16, 2008
November 30, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
To examine whether the extent of irreversible myocardial injury as assessed by Delayed Enhancement Magnetic Resonance Imaging can predict the extent of functional recovery after revascularization in patients with chronic coronary artery disease (CAD).
36 months
Eligibility Criteria
Patients were recruited from 9 institutions on 3 different continent. All patients recruited for the study had a history of angiographically documented chronic coronary artery disease and resting wall motion abnormalities, and were scheduled for cardiac revascularization (coronary artery bypass surgery or percutaneous intervention).
You may qualify if:
- Age: \> 21 years and \< 85 years
- Sinus rhythm
- Weight \< 120 kg
- LVEF \> 30%
- Wall motion abnormality on Echo. or LV-gram
- Scheduled for revascularization - Angioplasty/Stent or CABG - within 30 days
You may not qualify if:
- Resting heart rate \> 100 bpm
- Frequent atrial or ventricular ectopy
- Severe aortic stenosis or HOCM
- Unstable angina
- Myocardial infarction within 14 days
- Active congestive heart failure
- Pregnancy
- Known allergy to gadolinium
- Contraindication to MRI
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- CHI St. Luke's Health, Texaslead
- Medtronic - MITGcollaborator
Study Sites (7)
St. Luke's Episcopal Hospital
Houston, Texas, 77030, United States
St. Luke's Episcopal Location
Houston, Texas, 77030, United States
Cliniques Universitaires St. Luc
Brussels, B-1200, Belgium
Skejby University Hospital
Aarhus N, 8200, Denmark
Hygeia Hospital
Marousi, 15123, Greece
Siriraj Hospital
Bangkoknoi, Bangkok, 10700, Thailand
Cardiac MRI Unit
Leeds, LS1 3EX, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Scott D Flamm, M.D.
CHI St. Luke's Health, Texas
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
April 16, 2008
First Posted
April 18, 2008
Study Start
August 11, 2003
Primary Completion
January 14, 2011
Study Completion
May 15, 2011
Last Updated
December 2, 2020
Record last verified: 2020-11