MRI Study With Ferumoxytol in Assessing Early Response in Patients With Glioblastoma Multiforme Receiving Temozolomide and Radiation Therapy
Early Assessment of Tumor Response to Therapy Using Ferumoxytol (Code 7228) as an MR Contrast Agent in Patients With Glioblastoma Multiforme (MedDRA Code 10018337)
8 other identifiers
interventional
14
1 country
1
Brief Summary
This pilot clinical trial studies how a magnetic resonance imaging (MRI) study with ferumoxytol works as a contrasting agent in assessing early response in patients with glioblastoma multiforme receiving temozolomide and radiation therapy. Ferumoxytol is a very small form of iron particles that are injected into the body and taken up by certain tissues which may make these tissues easier to see during imaging. Diagnostic procedures, such as an MRI study with ferumoxytol, may help measure a patient's response to earlier treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Dec 2006
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2006
CompletedFirst Submitted
Initial submission to the registry
April 10, 2008
CompletedFirst Posted
Study publicly available on registry
April 17, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2014
CompletedResults Posted
Study results publicly available
May 16, 2016
CompletedMay 16, 2017
April 1, 2017
7.5 years
April 10, 2008
February 12, 2016
April 19, 2017
Conditions
Outcome Measures
Primary Outcomes (2)
Mean Cerebral Blood Volume (CBV)
Radiographical progression is determined based on RANO criteria.
At radiographical progression (between 6 and 12 weeks post first dose of chemoradiation)
Tumor Progression on Conventional MR
Tumor progression was assessed by RANO criteria (Wen, 2010).
Anytime between baseline and 12 weeks post treatment initiation: average 6 weeks post treatment initiation.
Study Arms (3)
Ferumoxytol
EXPERIMENTALPatients receive ferumoxytol non-stoichiometric magnetite IV on day 2 then undergo DSC MRI, and DCE MRI, DWI (day 1 only), and TOF MR angiography on days 1-3 at 4 time points: before radiation, 3 weeks after initiation of radiation plus temozolomide, at the end of radiation (6 weeks post first dose) and 6 weeks after radiation (12 weeks post first dose). Ferumoxytol non-stoichiometric magnetite administration continues in the absence of unacceptable toxicity.
Gadoteridol
ACTIVE COMPARATORPatients receive gadoteridol IV on day 1 then undergo DSC MRI, and DCE MRI, DWI (day 1 only), and TOF MR angiography on days 1-3 at 4 time points: before radiation, 3 weeks after initiation of radiation plus temozolomide, at the end of radiation (6 weeks post first dose) and 6 weeks after radiation (12 weeks post first dose).
Gadoteridol Leakage Corrected
ACTIVE COMPARATORPatients receive gadoteridol IV on day 1 then undergo DSC MRI, and DCE MRI, DWI (day 1 only), and TOF MR angiography on days 1-3 at 4 time points: before radiation, 3 weeks after initiation of radiation plus temozolomide, at the end of radiation (6 weeks post first dose) and 6 weeks after radiation (12 weeks post first dose).
Interventions
Given IV
Undergo DCE MRI
Undergo DSC MRI
Undergo DWI
Undergo TOF MR angiography
Eligibility Criteria
You may qualify if:
- Patients must have radiologically and histologically confirmed diagnosis of glioblastoma multiforme
- Patients must have measurable disease, defined as evident tumors with gadolinium enhancement on MRI that is measurable in at least one diameter and visible on both axial and sagittal or coronal views
- Life expectancy of greater than 6 months
- Eastern Cooperative Oncology Group (ECOG) performance status =\< 2 (Karnofsky \>= 50%)
- Patients scheduled for standard therapy (6 weeks radiation therapy (RT) \~ 60 Gy, plus temozolomide 75 mg/m\^2 during 6 week \[w\] RT, and followed routine monthly temozolomide therapy)
- Patients must be on a stable or decreasing dose (up to 8 mg daily) of dexamethasone throughout the study
- After entry into the study, patients are expected to be followed for at least 1 month after the last infusion of ferumoxytol
- Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately
- Ability to understand and the willingness to sign a written informed consent document; all patients, or their legal guardians, must sign a written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization in accordance with institutional guidelines
You may not qualify if:
- Patients who have had chemotherapy or radiotherapy
- Patients may not be receiving any other investigational agents
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to ferumoxytol: parenteral iron, parenteral dextran, parenteral iron-dextran, or parenteral iron-polysaccharide preparations (Ferumoxytol Investigator's Drug Brochure, 2005); patients with significant drug or other allergies or autoimmune diseases may be enrolled at the Investigator's discretion
- Patients with clinically significant signs of uncal herniation, such as acute pupillary enlargement, rapidly developing motor changes (over hours), or rapidly decreasing level of consciousness, are not eligible
- Patients who require monitored anesthesia for MRI scanning
- Patients with history of hemochromatosis or iron overload
- Patients with renal insufficiency (glomerular filtration rate (GFR) \< 50)
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with ferumoxytol
- Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- OHSU Knight Cancer Institutelead
- National Cancer Institute (NCI)collaborator
Study Sites (1)
OHSU Knight Cancer Institute
Portland, Oregon, 97239, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Edward Neuwelt
- Organization
- Oregon Health and Science University
Study Officials
- PRINCIPAL INVESTIGATOR
Edward Neuwelt
OHSU Knight Cancer Institute
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
April 10, 2008
First Posted
April 17, 2008
Study Start
December 1, 2006
Primary Completion
June 1, 2014
Study Completion
June 1, 2014
Last Updated
May 16, 2017
Results First Posted
May 16, 2016
Record last verified: 2017-04