Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement
MyRiAD
Study of Myeloid-related Protein 8/14 and Additional Biomarkers (Multi Marker Approach) for Early Diagnosis and Risk Stratification in Patients Presenting With Acute Chest Pain at the Emergency Department
1 other identifier
observational
403
1 country
1
Brief Summary
The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk stratification in patients presenting with acute chest pain at the emergency department. Study hypothesis: MRP 8/14, alone or together with other established or new biomarkers, increases the earliness, sensitivity, and specificity of diagnosing acute coronary syndromes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2008
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2008
CompletedFirst Submitted
Initial submission to the registry
April 8, 2008
CompletedFirst Posted
Study publicly available on registry
April 14, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2010
CompletedMay 31, 2012
May 1, 2012
2.8 years
April 8, 2008
May 30, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Diagnosis of acute coronary syndrome
Emergency room and/or hospital stay
Secondary Outcomes (3)
Incidence of any acute coronary event
1 year
Morbidity from coronary artery disease
1 year
Mortality
1 year
Eligibility Criteria
Consecutive patients - systematic sampling - presenting with acute chest pain at the emergency room in which determination of cardiac biomarkers is indicated for clinical diagnostics
You may qualify if:
- All patients in the emergency department of the University Hospital Zurich with measurement of troponin during the routine diagnostic evaluation.
You may not qualify if:
- Refusal or inability to give informed consent.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Zurichlead
- Swiss National Science Foundationcollaborator
Study Sites (1)
Cardiology, University Hospital
Zurich, 8091, Switzerland
Related Publications (1)
Altwegg LA, Neidhart M, Hersberger M, Muller S, Eberli FR, Corti R, Roffi M, Sutsch G, Gay S, von Eckardstein A, Wischnewsky MB, Luscher TF, Maier W. Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. Eur Heart J. 2007 Apr;28(8):941-8. doi: 10.1093/eurheartj/ehm078. Epub 2007 Mar 26.
PMID: 17387139BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Willibald Maier, MD
Cardiology, University Hospital Zurich
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 8, 2008
First Posted
April 14, 2008
Study Start
March 1, 2008
Primary Completion
December 1, 2010
Study Completion
December 1, 2010
Last Updated
May 31, 2012
Record last verified: 2012-05