Racial Differences: Nitric Oxide(NO) and Endothelin-1(ET-1) in Preeclampsia (PreE)

NCT00653809 | Completed

• 1 other identifier: 2007-0065
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to examine the activation of markers of endothelial and cardiovascular dysfunctions, from women with high-risk pregnancies. Information from this study will hopefully provide enough information to determine a link between race, the advent of high risk pregnancies and cardiovascular markers. With this information it might be possible to intervene with approved pharmacological treatments.

Conditions

Preeclampsia

Outcome Measures

Primary Outcomes (1)

• Nitric oxide and Endothelin-1 levels

  48 hours after tissue collection

Secondary Outcomes (1)

• Nitric oxide isoforms and Endothelin-1 receptor activation based on primary outcome

  within 6 months from tissue collection

Study Arms (8)

A, 1, I

Caucasian women without preeclampsia or PIH, delivering their first child

A, 1, II

Caucasian women with preeclampsia or PIH, delivering their first child

A, 2, I

African-american women without preeclampsia or PIH, delivering their first child

A, 2, II

African-American women with preeclampsia or PIH, delivering their first child

B, 1, I

Caucasian women without preeclampsia or PIH, delivering at least their second child

B, 1, II

Caucasian women with preeclampsia or PIH, delivering at least their second child

B, 2, I

African-american women without preeclampsia or PIH, delivering at least their second child

B, 2, II

African-american women with preeclampsia or PIH, delivering at least their second child

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women delivering babies at the University of MS Medical Center

You may qualify if:

• African-american or Caucasian
• Pregnant
• Between ages of 18 - 40 years of age

You may not qualify if:

• Presence of a disease or condition which is not preeclampsia
• Drug or alcohol abuse during pregnancy
• Obesity

Sponsors & Collaborators

• University of Mississippi Medical Center: lead
• Office of Minority Health: collaborator
• Mississippi Institute for Improvement of Geographic Minority Health: collaborator

Study Sites (1)

University of MS Medical Center

Jackson, Mississippi, 39216, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Placental Tissue

MeSH Terms

Conditions

Pre-Eclampsia

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Kedra L Wallace, PhD

  Obstetrics & Gynecology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Postdoc Research Fellow

Study Record Dates

• First Submitted: April 1, 2008
• First Posted: April 7, 2008
• Study Start: June 1, 2007
• Primary Completion: December 1, 2008
• Study Completion: September 1, 2009
• Last Updated: April 6, 2012

Record last verified: 2012-04

Locations

US (1)