Characterizing Methamphetamine Withdrawal in Recently Abstinent Methamphetamine Users: A Pilot Study

NCT00653263 | Completed Results DMC

• 2 other identifiers: 51178Alcohol & Substance Dependence
• Study Type: observational
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

Methamphetamine use has escalated in recent years. Methamphetamine use has also spread throughout the country. Although much information has been gathered on the treatment of cocaine abuse, very little information has been obtained on the treatment of methamphetamine abuse. One of the first steps in developing appropriate treatment is to examine the effects of stopping a particular substance's use on individuals abusing that substance. To date this has not been well studied for people abusing methamphetamine. The purpose of this study is to better understand and develop accurate ways of measuring symptoms associated with stopping the use of methamphetamine in people that are abusing methamphetamine. If the withdrawal symptoms are able to be effectively measured, this will help to develop treatments targeted at alleviating these symptoms. These symptoms are often associated with relapse to use of that substance.

Conditions

Methamphetamine Dependence; Methamphetamine Withdrawal

Keywords

methamphetamine; drug abuse; withdrawal

Outcome Measures

Primary Outcomes (2)

• Methamphetamine Selective Severity Assessment (MSSA)

  Methamphetamine Selective Severity Assessment (MSSA) is an 18 item questionnaire assessing withdrawal symptoms with each question measured on a scale from 0(best score)-7(worst score) for a range in scores from 0(best score)-126(worst score). Higher scores indicate more severe withdrawal symptoms.

  Baseline through week 4

• Methamphetamine Withdrawal Assessment (MAWA)

  The Methamphetamine Withdrawal Assessment (MAWA) is a 13 item questionnaire which measures symptoms of methamphetamine withdrawal on a scale from 0(best score)-4(worst score). The total score ranges from 0(best score)-52(worst score).

  Baseline through week 4

Secondary Outcomes (1)

• Hamilton Depression Rating Scale (HAM-D) Rating Score

  4 weeks

Study Arms (1)

Methamphetamine dependent

Methamphetamine dependent participants admitted to Recovery Centers of Arkansas

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We will enroll 20 methamphetamine dependent individuals ages 18-65 recruited from those admitted to the Recovery Centers of Arkansas in North Little Rock.

You may qualify if:

• years old
• Subjects must have a history of methamphetamine use, with recent use verified by a urine toxicology screen positive for amphetamines

You may not qualify if:

• Current diagnosis of drug or alcohol physical dependence (other than methamphetamine or tobacco)
• Schizophrenia, or bipolar type I disorder
• Present or recent use of over-the-counter or prescription psychoactive drug or drug(s) that may affect mood ratings
• Current suicidality or psychosis
• Pregnancy: hormonal changes during pregnancy can affect mood which might produce a potential confound if pregnant women were enrolled

Sponsors & Collaborators

• University of Arkansas: lead

Study Sites (1)

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

Location

MeSH Terms

Conditions

Substance-Related Disorders

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders

Limitations and Caveats

The small sample size (N=6) is a significant limitation of the current study.

Results Point of Contact

• Title: Michael J Mancino
• Organization: UArkansas

mjmancino@uams.edu

501-526-8442

Study Officials

• Michael J Mancino, M.D.

  University of Arkansas

  PRINCIPAL INVESTIGATOR

• Alison Oliveto, PhD

  University of Arkansas

  STUDY CHAIR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 1, 2008
• First Posted: April 4, 2008
• Study Start: August 1, 2006
• Primary Completion: August 1, 2008
• Study Completion: August 1, 2008
• Last Updated: June 28, 2021
• Results First Posted: March 9, 2010

Record last verified: 2010-02

Locations

US (1)