Memory and the Hippocampus in Twins

NCT00638885 | Completed Results DMC

• 1 other identifier: MHBA-008-07S
• Study Type: observational
• Target: 142
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this project is to measure brain markers and cognitive factors in twins with a history of military service with and without PTSD, and to follow them over time and measure changes in brain function and cognitive variables.

Conditions

PTSD; Stress Disorders, Post-Traumatic

Keywords

PTSD; hippocampus; twins

Outcome Measures

Primary Outcomes (1)

• Neuropsychological Testing of Memory

  Percent retention on the Wechsler Memory Scale - Logical

  2 days

Study Arms (1)

Group 1

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Twins with history of military service during Vietnam era with and without PTSD

You may qualify if:

• All twins will be required to give written informed consent.
• Subjects will be included with a history of Vietnam Era service.
• All subjects must be free of major medical illness on the basis of history and physical examination, lab testing, and electrocardiogram.

You may not qualify if:

• Subjects will be excluded with a history of shrapnel or other foreign bodies that would preclude MRI scanning, history of loss of consciousness, or neuroleptics, sedative or benzodiazepine medication usage within the previous four weeks.
• Subjects will also be excluded if based on the SCID interview they have comorbid:
• schizophrenia;
• schizoaffective disorder;
• bulimia or anorexia, or
• bipolar disorder.
• Subjects will also be excluded with a history of blast injury with associated traumatic brain injury.
• In addition, subjects will be excluded with a history of alcohol or substance abuse/dependence within the past year. We will use the strategy used in prior MRI studies and use multivariate analyses to examine the contribution of past histories of alcohol and substance abuse (as measured with the Addiction Severity Index) and depression symptom level (as measured with the Hamilton Depression Scale) to the outcomes of interest.
• Subjects will be excluded from the study if they present with a history of serious medical or neurological illness, or as a result of routine laboratory studies, history of asthma, steroid usage, seizure disorder, or prenatal/perinatal substance exposure or trauma.

Sponsors & Collaborators

• US Department of Veterans Affairs: lead

Study Sites (1)

Atlanta VA Medical and Rehab Center, Decatur

Decatur, Georgia, 30033, United States

Location

Related Links

• J. Douglas Bremner, M.D. Website

Biospecimen

Retention: SAMPLES WITH DNA

blood for genetic testing, blood samples and urine and saliva collections

MeSH Terms

Conditions

Stress Disorders, Post-Traumatic

Condition Hierarchy (Ancestors)

Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Mental Disorders

Results Point of Contact

• Title: J Douglas Bremner MD
• Organization: Atlanta VAMC

jdbremn@emory.edu

404-712-9569

Study Officials

• Doug Bremner, MD

  Atlanta VA Medical and Rehab Center, Decatur

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: FED
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2008
• First Posted: March 19, 2008
• Study Start: April 1, 2010
• Primary Completion: June 1, 2012
• Study Completion: June 1, 2013
• Last Updated: January 15, 2015
• Results First Posted: January 15, 2015

Record last verified: 2015-01

Locations

US (1)