Single Transpulmonary Thermodilution and Continuous Monitoring of Central Venous Oxygen Saturation During Off-pump Coronary Surgery
OPCAB
2 other identifiers
interventional
40
1 country
1
Brief Summary
The aim of the present study was to evaluate the usefulness of an algorithm based on hemodynamic parameters obtained by single transpulmonary thermodilution (STD) combined with continuous monitoring of central venous oxygen saturation (ScvO2) for perioperative management of patients undergoing OPCAB.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable coronary-artery-disease
Started May 2005
Typical duration for not_applicable coronary-artery-disease
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2005
CompletedFirst Submitted
Initial submission to the registry
February 13, 2008
CompletedFirst Posted
Study publicly available on registry
February 27, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2008
CompletedMarch 22, 2024
March 1, 2024
3.3 years
February 13, 2008
March 20, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
length of hospital stay
Length of the hospital stays, Days
one month
Study Arms (2)
Conventional monitoring
ACTIVE COMPARATORhemodynamic monitoring - conventional monitoring
Advanced monitoring
ACTIVE COMPARATORhemodynamic monitoring - advanced monitoring
Interventions
In the CM group, therapy was guided by central venous pressure, mean arterial pressure (MAP) and heart rate (HR)
In the AM group by the intrathoracic blood volume index, MAP, HR, central venous oxygen saturation (ScvO2) and cardiac index (CI). The measurements were performed before and during surgery, and at 2, 4 and 6 hrs post-operatively.
Eligibility Criteria
You may qualify if:
- Patients with coronary artery disease, ranked ASA II-III and scheduled for elective OPCAB
You may not qualify if:
- Age \< 18 years
- Severe valve dysfunction or peripheral vascular disease
- Simultaneous interventions (carotid endarterectomy, aneurysm repair, etc.)
- Transfer to CPB during surgery
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Northern State Medical Universitylead
- University of Tromsocollaborator
Study Sites (1)
Dep. of Anesthesiology, Northern SMU
Arkhangelsk, 163000, Russia
Related Publications (1)
Smetkin AA, Kirov MY, Kuzkov VV, Lenkin AI, Eremeev AV, Slastilin VY, Borodin VV, Bjertnaes LJ. Single transpulmonary thermodilution and continuous monitoring of central venous oxygen saturation during off-pump coronary surgery. Acta Anaesthesiol Scand. 2009 Apr;53(4):505-14. doi: 10.1111/j.1399-6576.2008.01855.x. Epub 2009 Jan 15.
PMID: 19183113RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Mikhail Y Kirov
Northern SMU
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. M.Y. Kirov, MD, PhD
Study Record Dates
First Submitted
February 13, 2008
First Posted
February 27, 2008
Study Start
May 1, 2005
Primary Completion
August 1, 2008
Study Completion
September 1, 2008
Last Updated
March 22, 2024
Record last verified: 2024-03