NCT00620958

Brief Summary

This study will compare the effectiveness of individual cognitive behavioral therapy with two distinct types of parent involvement versus individual cognitive behavioral therapy without parent involvement in treating children with anxiety disorders. Hypothesized mediator of change for eac of the two parent treatment conditions also will be evaluated

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
341

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Aug 2008

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 20, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

February 22, 2008

Completed
5 months until next milestone

Study Start

First participant enrolled

August 1, 2008

Completed
8.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2016

Completed
Last Updated

August 2, 2017

Status Verified

July 1, 2017

Enrollment Period

8.3 years

First QC Date

February 20, 2008

Last Update Submit

July 31, 2017

Conditions

Keywords

MediationOutcomeCBTChild Anxiety Intervention

Outcome Measures

Primary Outcomes (1)

  • Clinician Severity Rating on the Anxiety Disorders Interview Schedule for Children (ADIS C/P)

    Measured at pretreatment, midtreatment, post-treatment, and Year 1 follow up

Secondary Outcomes (1)

  • Child Manifest Anxiety Scale for Children, Revised

    Measured at pretreatment, midtreatment, post-treatment, and Year 1 follow up

Study Arms (3)

1

EXPERIMENTAL

Participants will receive individual cognitive behavioral therapy with parent reinforcement training.

Behavioral: Parent reinforcement training (PRT1) With Individual Cognitive Behavioral Therapy (ICBT)

2

EXPERIMENTAL

Participants will receive individual cognitive behavioral therapy with parent relationship training.

Behavioral: Parent relationship training (PRT2) With Individual Cognitive Behavioral Therapy (ICBT)

3

ACTIVE COMPARATOR

Participants will receive individual cognitive behavioral therapy alone.

Behavioral: Individual cognitive behavioral therapy (ICBT)

Interventions

ICBT will include 12 to 14 sessions during which child participants will learn how to change anxious and fearful thoughts and to deal with feared objects and events.

Also known as: CBT
3

Parent relationship training will teach the parent ways to communicate with the child and to solve problems to help discourage child avoidant behaviors. ICBT will include 12 to 14 sessions during which child participants will learn how to change anxious and fearful thoughts and to deal with feared objects and events.

2

Parent reinforcement training will teach the parent strategies for managing the child's behavior through the use of positive rewards and positive parental behaviors to help discourage child avoidant behaviors. ICBT will include 12 to 14 sessions during which child participants will learn how to change anxious and fearful thoughts and to deal with feared objects and events.

1

Eligibility Criteria

Age8 Years - 11 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Meets DSM-IV criteria for a primary diagnosis of an anxiety disorder, including generalized anxiety disorder (GAD), social phobia (SOP), and social anxiety disorder (SAD), as confirmed by ADIS C/P
  • Receives a mean score of 4 or greater on the Clinician's Rating Scale of Severity (CSR)
  • Willing to stop all other child psychosocial treatment upon study entry
  • Comorbid attention deficit hyperactivity disorder (ADHD) and depressive disorders with CSR scores less than 4 are acceptable if treated and stable
  • Tics or aggression/impulse control problems with minimal or no impairment are acceptable if treated and stable
  • If taking medication, on stable medication treatment for comorbid ADHD, major depressive disorder, tics, or aggression/impulse control
  • Agreement of parents or guardians to participate in the child participant's treatment
  • Child living with a primary caregiver who has known the child well for at least 6 months and who is legally able to give consent for the child's participation

You may not qualify if:

  • Meets as a primary diagnosis any Axis I DSM-IV disorder other than GAD, SOP, and SAD
  • Child and/or parent meets diagnoses (e.g., primary, secondary, tertiary) for any one of the following: pervasive developmental disorders, mental retardation, selective mutism, organic mental disorders, schizophrenia, and other psychotic disorders
  • Child and/or parent shows high likelihood and/or serious intent of hurting self or others
  • Full-scale IQ score less than 80
  • Victim of previously undisclosed abuse requiring investigation or ongoing supervision by the Department of Social Services

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Florida International University

Miami, Florida, 33139, United States

Location

Related Publications (1)

  • Patriarca GC, Rey Y, Marin CE, Yeguez CE, Pettit JW, Silverman WK. Parent involvement enhances CBTs for anxiety disorders in Hispanic/Latino youth: Acculturation as a moderator. J Consult Clin Psychol. 2022 Oct;90(10):827-836. doi: 10.1037/ccp0000770.

MeSH Terms

Conditions

Anxiety DisordersNegotiating

Interventions

Eukaryotic Initiation Factor-3

Condition Hierarchy (Ancestors)

Mental DisordersCommunicationBehavior

Intervention Hierarchy (Ancestors)

Eukaryotic Initiation FactorsPeptide Initiation FactorsRibosomal ProteinsProteinsAmino Acids, Peptides, and Proteins

Study Officials

  • Wendy K. Silverman, PhD

    Florida International University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

February 20, 2008

First Posted

February 22, 2008

Study Start

August 1, 2008

Primary Completion

December 1, 2016

Study Completion

December 1, 2016

Last Updated

August 2, 2017

Record last verified: 2017-07

Locations