Hypothalamo-, Pituitary-, Adrenal Axis Dysfunction in Subarachnoid Hemorrhage

NCT00614887 | Completed DMC

• 2 other identifiers: KUH50701845070184
• Study Type: observational
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

Subarachnoid haemorrhage (SAH) may cause damage to the hypotalamo-pituitary-adrenal axis (HPA) thus disturbing the hormonal response of these structures. The aim of our study is to characterize the function of HPA-axis acutely and over time up to three months in patients with SAH.

Conditions

Subarachnoid Hemorrhage; Cerebral Aneurysm

Keywords

Subarachnoid hemorrhage; Pituitary gland; Adrenal gland

Study Arms (2)

2

Patients scheduled for elective cerebral aneurysmal surgery

1

Patients with subarachnoid hemorrhage

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients suffering from acute subarachnoid hemorrhage and patients admitted for elective aneurysm surgery.

You may qualify if:

• SAH-group:
• \>age 18,
• Subarachnoid hemorrhage due to an cerebral aneurysm
• Control group:
• Age \>18
• Admitted for elective primary cerebral aneurysm surgery

You may not qualify if:

• SAH group:
• Any corticoid treatment (also inhaled)
• Usage of etomidate before study entry or during the study period
• Exact bleeding day unknown
• Previous history of SAH or more than three days of current bleeding
• Previous aneurysm surgery or embolization
• Traumatic SAH
• Known pituitary insufficiency and moribund state of the patient
• Refusement of the patient
• control group:
• Any corticoid treatment (also inhaled)
• Usage of etomidate before study entry or during the study period
• Previous history of SAH or cerebral aneurym surgery or embolization
• Admitted for elective aneurysm embolization
• Known pituitary insufficiency

Sponsors & Collaborators

• Kuopio University Hospital: lead
• University of Eastern Finland: collaborator

Study Sites (1)

Department of Intensive Care, Kuopio University Hospital

Kuopio, PL 1777, 70211, Finland

Location

Related Publications (2)

• Bendel S, Koivisto T, Ryynanen OP, Ruokonen E, Romppanen J, Kiviniemi V, Uusaro A. Insulin like growth factor-I in acute subarachnoid hemorrhage: a prospective cohort study. Crit Care. 2010;14(2):R75. doi: 10.1186/cc8988. Epub 2010 Apr 28.

  PMID: 20426845 DERIVED

• Bendel S, Koivisto T, Ruokonen E, Rinne J, Romppanen J, Vauhkonen I, Kiviniemi V, Uusaro A. Pituitary-adrenal function in patients with acute subarachnoid haemorrhage: a prospective cohort study. Crit Care. 2008;12(5):R126. doi: 10.1186/cc7084. Epub 2008 Oct 13.

  PMID: 18851750 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum and plasma samples

MeSH Terms

Conditions

Subarachnoid Hemorrhage; Intracranial Aneurysm; Pituitary Diseases

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Intracranial Arterial Diseases; Aneurysm; Hypothalamic Diseases; Endocrine System Diseases

Study Officials

• Stepani J Bendel, MD

  Department of Intensive Care, Kuopio University Hospital, FINLAND

  PRINCIPAL INVESTIGATOR

• Ari Uusaro, MD, Phd

  Department of Intensive Care, Kuopio University Hospital, FINLAND

  STUDY DIRECTOR

• Timo Koivisto, MD, Phd

  Department of Neurosurgery, Kuopio Universtiy Hospital, FINLAND

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 31, 2008
• First Posted: February 13, 2008
• Study Start: March 1, 2006
• Primary Completion: November 1, 2006
• Study Completion: January 1, 2008
• Last Updated: October 26, 2023

Record last verified: 2008-01

Locations

FI (1)