NCT00614575

Brief Summary

The primary objective of this investigation is to conduct a 12-week prospective survey in PD patients with depressive symptoms treated with BI Sifrol Tablets (hereinafter referred to as this drug) in the routine clinical settings to determine the following items related to the safety and efficacy. i. Adverse drug reaction symptoms, incidence, and severity ii. Motor capacity during the investigation iii. Depressive symptoms during the investigation

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,089

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

238 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2007

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

January 31, 2008

Completed
13 days until next milestone

First Posted

Study publicly available on registry

February 13, 2008

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2009

Completed
2 years until next milestone

Results Posted

Study results publicly available

July 19, 2011

Completed
Last Updated

August 6, 2014

Status Verified

August 1, 2014

Enrollment Period

2.6 years

First QC Date

January 31, 2008

Results QC Date

February 23, 2011

Last Update Submit

August 1, 2014

Conditions

Outcome Measures

Primary Outcomes (1)

  • Percentage of Participants With Adverse Events, Adverse Drug Reactions, and Serious Adverse Events

    The aim of this Post Marketing Surveillance (PMS) was to obtain safety data with treatment of pramipexole in Parkinson's disease patients with depressive symptoms. The percentage of participants with adverse events, adverse drug reactions, and serious adverse events are presented.

    for 12 weeks

Secondary Outcomes (5)

  • Clinical Global Impression of Improvement

    for 12 weeks after initiation of the treatment

  • Mean Change From Baseline in Unified Parkinson's Disease Rating Scale (UPDRS) Part III Total Score

    Baseline and after 12 weeks (or at the time of discontinuation)

  • Mean Change From Baseline in Beck's Depression Inventory (BDI) Total Score

    Baseline and after 12 weeks (or at the time of discontinuation)

  • Mean Change From Baseline in UPDRS (Unified Parkinson's Disease Rating Scale) Part I Item 3 Score

    Baseline and after 12 weeks (or at the time of discontinuation)

  • Mean Change From Baseline in Modified Hoehn & Yahr Rating Scale

    After 12 weeks or at the time of discontinuation

Study Arms (1)

BI-Sifrol® Tablets (Pramipexole)

BI-Sifrol® Tablets, pramipexole dose: 0.125 mg, 0.5 mg, No reference therapy

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

PD patients with depressive symptoms

You may qualify if:

  • \*\*PD patients with depressive symptoms Patients who have not received pramipexole hydrochloride hydrate preparations within 1 month before survey entrance.

You may not qualify if:

  • PD patients with the past history of suicidal attempt, suicidal ideation or tendency
  • PD patients with suicidal ideation
  • PD patients with the past history of suicidal tendency

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (238)

Boehringer Ingelheim Investigational Site

Akashi, Japan

Location

Boehringer Ingelheim Investigational Site 1

Akita, Japan

Location

Boehringer Ingelheim Investigational Site 2

Akita, Japan

Location

Boehringer Ingelheim Investigational Site

Asahikawa, Japan

Location

Boehringer Ingelheim Investigational Site

Ashikaga, Japan

Location

Boehringer Ingelheim Investigational Site

Awaji, Japan

Location

Boehringer Ingelheim Investigational Site

Chitose, Japan

Location

Boehringer Ingelheim Investigational Site

Chūō, Japan

Location

Boehringer Ingelheim Investigational Site 1

Fuchū, Japan

Location

Boehringer Ingelheim Investigational Site 2

Fuchū, Japan

Location

Boehringer Ingelheim Investigational Site

Fuefuki, Japan

Location

Boehringer Ingelheim Investigational Site

Fuehuki, Japan

Location

Boehringer Ingelheim Investigational Site

Fujioka, Japan

Location

Boehringer Ingelheim Investigational Site

Fujisaki, Japan

Location

Boehringer Ingelheim Investigational Site

Fujisawa, Japan

Location

Boehringer Ingelheim Investigational Site

Fukaya, Japan

Location

Boehringer Ingelheim Investigational Site 1

Fukuoka, Japan

Location

Boehringer Ingelheim Investigational Site 2

Fukuoka, Japan

Location

Boehringer Ingelheim Investigational Site 3

Fukuoka, Japan

Location

Boehringer Ingelheim Investigational Site 4

Fukuoka, Japan

Location

Boehringer Ingelheim Investigational Site 5

Fukuoka, Japan

Location

Boehringer Ingelheim Investigational Site 1

Fukushima, Japan

Location

Boehringer Ingelheim Investigational Site 2

Fukushima, Japan

Location

Boehringer Ingelheim Investigational Site

Funabashi, Japan

Location

Boehringer Ingelheim Investigational Site 1

Gifu, Japan

Location

Boehringer Ingelheim Investigational Site 2

Gifu, Japan

Location

Boehringer Ingelheim Investigational Site

Habikino, Japan

Location

Boehringer Ingelheim Investigational Site

Hachiōji, Japan

Location

Boehringer Ingelheim Investigational Site 1

Hamamatsu, Japan

Location

Boehringer Ingelheim Investigational Site 2

Hamamatsu, Japan

Location

Boehringer Ingelheim Investigational Site 3

Hamamatsu, Japan

Location

Boehringer Ingelheim Investigational Site 4

Hamamatsu, Japan

Location

Boehringer Ingelheim Investigational Site 5

Hamamatsu, Japan

Location

Boehringer Ingelheim Investigational Site

Hanamaki, Japan

Location

Boehringer Ingelheim Investigational Site

Hayashima, Japan

Location

Boehringer Ingelheim Investigational Site 1

Higashiosaka, Japan

Location

Boehringer Ingelheim Investigational Site 2

Higashiosaka, Japan

Location

Boehringer Ingelheim Investigational Site

Himeji, Japan

Location

Boehringer Ingelheim Investigational Site

Hirakata, Japan

Location

Boehringer Ingelheim Investigational Site

Hirishima, Japan

Location

Boehringer Ingelheim Investigational Site

Hirosaki, Japan

Location

Boehringer Ingelheim Investigational Site

Ibaraki, Japan

Location

Boehringer Ingelheim Investigational Site

Iizuka, Japan

Location

Boehringer Ingelheim Investigational Site

Inag, Japan

Location

Boehringer Ingelheim Investigational Site

Irima, Japan

Location

Boehringer Ingelheim Investigational Site

Isahaya, Japan

Location

Boehringer Ingelheim Investigational Site

Iwaki, Japan

Location

Boehringer Ingelheim Investigational Site

Iwamizawa, Japan

Location

Boehringer Ingelheim Investigational Site

Iwata, Japan

Location

Boehringer Ingelheim Investigational Site 1

Jyoetsu, Japan

Location

Boehringer Ingelheim Investigational Site 2

Jyoetsu, Japan

Location

Boehringer Ingelheim Investigational Site

Jyoyo, Japan

Location

Boehringer Ingelheim Investigational Site 1

Kagoshima, Japan

Location

Boehringer Ingelheim Investigational Site 2

Kagoshima, Japan

Location

Boehringer Ingelheim Investigational Site 3

Kagoshima, Japan

Location

Boehringer Ingelheim Investigational Site

Kahoku, Japan

Location

Boehringer Ingelheim Investigational Site

Kamakura, Japan

Location

Boehringer Ingelheim Investigational Site 1

Kanazawa, Japan

Location

Boehringer Ingelheim Investigational Site 2

Kanazawa, Japan

Location

Boehringer Ingelheim Investigational Site 1

Kanoya, Japan

Location

Boehringer Ingelheim Investigational Site 2

Kanoya, Japan

Location

Boehringer Ingelheim Investigational Site 1

Kashihara, Japan

Location

Boehringer Ingelheim Investigational Site 2

Kashihara, Japan

Location

Boehringer Ingelheim Investigational Site

Kasuga, Japan

Location

Boehringer Ingelheim Investigational Site

Kawagchi, Japan

Location

Boehringer Ingelheim Investigational Site

Kawaguchi, Japan

Location

Boehringer Ingelheim Investigational Site 1

Kawasaki, Japan

Location

Boehringer Ingelheim Investigational Site 2

Kawasaki, Japan

Location

Boehringer Ingelheim Investigational Site

Kitakami, Japan

Location

Boehringer Ingelheim Investigational Site 1

Kiyose, Japan

Location

Boehringer Ingelheim Investigational Site 2

Kiyose, Japan

Location

Boehringer Ingelheim Investigational Site

Kodaira, Japan

Location

Boehringer Ingelheim Investigational Site

Kofu, Japan

Location

Boehringer Ingelheim Investigational Site

Koga, Japan

Location

Boehringer Ingelheim Investigational Site

Komae, Japan

Location

Boehringer Ingelheim Investigational Site

Komatsu, Japan

Location

Boehringer Ingelheim Investigational Site

Komatsushima, Japan

Location

Boehringer Ingelheim Investigational Site

Koshigaya, Japan

Location

Boehringer Ingelheim Investigational Site 1

Kōriyama, Japan

Location

Boehringer Ingelheim Investigational Site 2

Kōriyama, Japan

Location

Boehringer Ingelheim Investigational Site

Kōtari, Japan

Location

Boehringer Ingelheim Investigational Site 1

Kumamoto, Japan

Location

Boehringer Ingelheim Investigational Site 2

Kumamoto, Japan

Location

Boehringer Ingelheim Investigational Site 3

Kumamoto, Japan

Location

Boehringer Ingelheim Investigational Site

Kure, Japan

Location

Boehringer Ingelheim Investigational Site

Kusatsu, Japan

Location

Boehringer Ingelheim Investigational Site 1

Kyoto, Japan

Location

Boehringer Ingelheim Investigational Site 2

Kyoto, Japan

Location

Boehringer Ingelheim Investigational Site 3

Kyoto, Japan

Location

Boehringer Ingelheim Investigational Site 4

Kyoto, Japan

Location

Boehringer Ingelheim Investigational Site

Maebashi, Japan

Location

Boehringer Ingelheim Investigational Site

Matsudo, Japan

Location

Boehringer Ingelheim Investigational Site

Matsumoto, Japan

Location

Boehringer Ingelheim Investigational Site

Mibu, Japan

Location

Boehringer Ingelheim Investigational Site

Mihara, Japan

Location

Boehringer Ingelheim Investigational Site

Mihoro, Japan

Location

Boehringer Ingelheim Investigational Site

Miriyama, Japan

Location

Boehringer Ingelheim Investigational Site

Misato, Japan

Location

Boehringer Ingelheim Investigational Site

Miyako, Japan

Location

Boehringer Ingelheim Investigational Site 1

Miyazaki, Japan

Location

Boehringer Ingelheim Investigational Site 2

Miyazaki, Japan

Location

Boehringer Ingelheim Investigational Site

Moriguchi, Japan

Location

Boehringer Ingelheim Investigational Site 1

Morioka, Japan

Location

Boehringer Ingelheim Investigational Site 2

Morioka, Japan

Location

Boehringer Ingelheim Investigational Site

Moriya, Japan

Location

Boehringer Ingelheim Investigational Site

Mukai-awagasaki, Japan

Location

Boehringer Ingelheim Investigational Site

Musashino, Japan

Location

Boehringer Ingelheim Investigational Site

Nagano, Japan

Location

Boehringer Ingelheim Investigational Site

Nagaoka, Japan

Location

Boehringer Ingelheim Investigational Site 1

Nagoya, Japan

Location

Boehringer Ingelheim Investigational Site 2

Nagoya, Japan

Location

Boehringer Ingelheim Investigational Site 3

Nagoya, Japan

Location

Boehringer Ingelheim Investigational Site 4

Nagoya, Japan

Location

Boehringer Ingelheim Investigational Site 1

Nara, Japan

Location

Boehringer Ingelheim Investigational Site 2

Nara, Japan

Location

Boehringer Ingelheim Investigational Site

Narashino, Japan

Location

Boehringer Ingelheim Investigational Site

Narita, Japan

Location

Boehringer Ingelheim Investigational Site

Narutō, Japan

Location

Boehringer Ingelheim Investigational Site

Nasushiobara, Japan

Location

Boehringer Ingelheim Investigational Site

Nichinan, Japan

Location

Boehringer Ingelheim Investigational Site

Ninohe, Japan

Location

Boehringer Ingelheim Investigational Site

Nishinomiya, Japan

Location

Boehringer Ingelheim Investigational Site

Nishitōkyō, Japan

Location

Boehringer Ingelheim Investigational Site

Okaya, Japan

Location

Boehringer Ingelheim Investigational Site 1

Okayama, Japan

Location

Boehringer Ingelheim Investigational Site 2

Okayama, Japan

Location

Boehringer Ingelheim Investigational Site

Okazaki, Japan

Location

Boehringer Ingelheim Investigational Site

Okinawa, Japan

Location

Boehringer Ingelheim Investigational Site

Omuta, Japan

Location

Boehringer Ingelheim Investigational Site 1

Osaka, Japan

Location

Boehringer Ingelheim Investigational Site 2

Osaka, Japan

Location

Boehringer Ingelheim Investigational Site 3

Osaka, Japan

Location

Boehringer Ingelheim Investigational Site 4

Osaka, Japan

Location

Boehringer Ingelheim Investigational Site 5

Osaka, Japan

Location

Boehringer Ingelheim Investigational Site 6

Osaka, Japan

Location

Boehringer Ingelheim Investigational Site

Ōgaki, Japan

Location

Boehringer Ingelheim Investigational Site

Ōiso, Japan

Location

Boehringer Ingelheim Investigational Site 1

Ōita, Japan

Location

Boehringer Ingelheim Investigational Site 2

Ōita, Japan

Location

Boehringer Ingelheim Investigational Site 3

Ōita, Japan

Location

Boehringer Ingelheim Investigational Site

Ōmura, Japan

Location

Boehringer Ingelheim Investigational Site

Ōnojō, Japan

Location

Boehringer Ingelheim Investigational Site

Ōta-ku, Japan

Location

Boehringer Ingelheim Investigational Site

Ōtake, Japan

Location

Boehringer Ingelheim Investigational Site

Ōtsu, Japan

Location

Boehringer Ingelheim Investigational Site

Ryūgasaki, Japan

Location

Boehringer Ingelheim Investigational Site

Saeki, Japan

Location

Boehringer Ingelheim Investigational Site

Saga, Japan

Location

Boehringer Ingelheim Investigational Site 1

Sagamihara, Japan

Location

Boehringer Ingelheim Investigational Site 2

Sagamihara, Japan

Location

Boehringer Ingelheim Investigational Site 3

Sagamihara, Japan

Location

Boehringer Ingelheim Investigational Site

Saijyo, Japan

Location

Boehringer Ingelheim Investigational Site

Saitama, Japan

Location

Boehringer Ingelheim Investigational Site 1

Sakai, Japan

Location

Boehringer Ingelheim Investigational Site 2

Sakai, Japan

Location

Boehringer Ingelheim Investigational Site 1

Sapporo, Japan

Location

Boehringer Ingelheim Investigational Site 2

Sapporo, Japan

Location

Boehringer Ingelheim Investigational Site 3

Sapporo, Japan

Location

Boehringer Ingelheim Investigational Site 4

Sapporo, Japan

Location

Boehringer Ingelheim Investigational Site 5

Sapporo, Japan

Location

Boehringer Ingelheim Investigational Site 6

Sapporo, Japan

Location

Boehringer Ingelheim Investigational Site 7

Sapporo, Japan

Location

Boehringer Ingelheim Investigational Site 8

Sapporo, Japan

Location

Boehringer Ingelheim Investigational Site 9

Sapporo, Japan

Location

Boehringer Ingelheim Investigational Site

Sekigahara, Japan

Location

Boehringer Ingelheim Investigational Site 1

Sendai, Japan

Location

Boehringer Ingelheim Investigational Site 2

Sendai, Japan

Location

Boehringer Ingelheim Investigational Site

Shimoda, Japan

Location

Boehringer Ingelheim Investigational Site 1

Shimotsuke, Japan

Location

Boehringer Ingelheim Investigational Site 2

Shimotsuke, Japan

Location

Boehringer Ingelheim Investigational Site

Shinngu, Japan

Location

Boehringer Ingelheim Investigational Site

Shiroishi, Japan

Location

Boehringer Ingelheim Investigational Site 1

Shizuoka, Japan

Location

Boehringer Ingelheim Investigational Site 2

Shizuoka, Japan

Location

Boehringer Ingelheim Investigational Site

Shōwajima, Japan

Location

Boehringer Ingelheim Investigational Site 1

Suita, Japan

Location

Boehringer Ingelheim Investigational Site 2

Suita, Japan

Location

Boehringer Ingelheim Investigational Site

Susono, Japan

Location

Boehringer Ingelheim Investigational Site

Suzuka, Japan

Location

Boehringer Ingelheim Investigational Site 1

Takaoka, Japan

Location

Boehringer Ingelheim Investigational Site 2

Takaoka, Japan

Location

Boehringer Ingelheim Investigational Site

Takatsuki, Japan

Location

Boehringer Ingelheim Investigational Site

Tarimizu, Japan

Location

Boehringer Ingelheim Investigational Site

Togitsu, Japan

Location

Boehringer Ingelheim Investigational Site

Tokoname, Japan

Location

Boehringer Ingelheim Investigational Site

Tokushima, Japan

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Boehringer Ingelheim Investigational Site

Tokyo Arakawa-ku, Japan

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Boehringer Ingelheim Investigational Site

Tokyo Bunkyo-ku, Japan

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Boehringer Ingelheim Investigational Site 1

Tokyo Chuo-ku, Japan

Location

Boehringer Ingelheim Investigational Site 2

Tokyo Chuo-ku, Japan

Location

Boehringer Ingelheim Investigational Site

Tokyo Daito-ku, Japan

Location

Boehringer Ingelheim Investigational Site

Tokyo Koto-ku, Japan

Location

Boehringer Ingelheim Investigational Site 1

Tokyo Meguro-ku, Japan

Location

Boehringer Ingelheim Investigational Site 2

Tokyo Meguro-ku, Japan

Location

Boehringer Ingelheim Investigational Site 1

Tokyo Minato-ku, Japan

Location

Boehringer Ingelheim Investigational Site 2

Tokyo Minato-ku, Japan

Location

Boehringer Ingelheim Investigational Site 3

Tokyo Minato-ku, Japan

Location

Boehringer Ingelheim Investigational Site

Tokyo Nakano-ku, Japan

Location

Boehringer Ingelheim Investigational Site

Tokyo Nerima-ku, Japan

Location

Boehringer Ingelheim Investigational Site 1

Tokyo Ota-ku, Japan

Location

Boehringer Ingelheim Investigational Site 2

Tokyo Ota-ku, Japan

Location

Boehringer Ingelheim Investigational Site

Tokyo Setagaya-ku, Japan

Location

Boehringer Ingelheim Investigational Site

Tokyo Setagaya, Japan

Location

Boehringer Ingelheim Investigational Site

Tokyo Shibuya-ku, Japan

Location

Boehringer Ingelheim Investigational Site

Tokyo Shinagawa-ku, Japan

Location

Boehringer Ingelheim Investigational Site 1

Tokyo Shinjyuku-ku, Japan

Location

Boehringer Ingelheim Investigational Site 2

Tokyo Shinjyuku-ku, Japan

Location

Boehringer Ingelheim Investigational Site 3

Tokyo Shinjyuku-ku, Japan

Location

Boehringer Ingelheim Investigational Site

Tokyo Sibuya-ku, Japan

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Boehringer Ingelheim Investigational Site

Tokyo Toshima-ku, Japan

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Boehringer Ingelheim Investigational Site

Tokyo-Edogawa-ku, Japan

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Boehringer Ingelheim Investigational Site

Tokyo-Itabashi-ku, Japan

Location

Boehringer Ingelheim Investigational Site

Toride, Japan

Location

Boehringer Ingelheim Investigational Site

Tosu, Japan

Location

Boehringer Ingelheim Investigational Site 1

Toyama, Japan

Location

Boehringer Ingelheim Investigational Site 2

Toyama, Japan

Location

Boehringer Ingelheim Investigational Site 3

Toyama, Japan

Location

Boehringer Ingelheim Investigational Site

Toyohashi, Japan

Location

Boehringer Ingelheim Investigational Site

Toyokawa, Japan

Location

Boehringer Ingelheim Investigational Site

Toyonaka, Japan

Location

Boehringer Ingelheim Investigational Site

Ube, Japan

Location

Boehringer Ingelheim Investigational Site

Ueda, Japan

Location

Boehringer Ingelheim Investigational Site

Ushiku, Japan

Location

Boehringer Ingelheim Investigational Site 1

Utsunomiya, Japan

Location

Boehringer Ingelheim Investigational Site 2

Utsunomiya, Japan

Location

Boehringer Ingelheim Investigational Site

Wakayama, Japan

Location

Boehringer Ingelheim Investigational Site 1

Yachiyo, Japan

Location

Boehringer Ingelheim Investigational Site 2

Yachiyo, Japan

Location

Boehringer Ingelheim Investigational Site 3

Yachiyo, Japan

Location

Boehringer Ingelheim Investigational Site

Yamanashi, Japan

Location

Boehringer Ingelheim Investigational Site

Yanago, Japan

Location

Boehringer Ingelheim Investigational Site

Yoichi, Japan

Location

Boehringer Ingelheim Investigational Site 1

Yokohama, Japan

Location

Boehringer Ingelheim Investigational Site 2

Yokohama, Japan

Location

Boehringer Ingelheim Investigational Site 3

Yokohama, Japan

Location

Boehringer Ingelheim Investigational Site 4

Yokohama, Japan

Location

Boehringer Ingelheim Investigational Site

Yokosuka, Japan

Location

Boehringer Ingelheim Investigational Site

Yoshinogawa, Japan

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Results Point of Contact

Title
Boehringer Ingelheim Call Center
Organization
Boehringer Ingelheim Pharmaceuticals

Study Officials

  • Boehringer Ingelheim

    Boehringer Ingelheim

    STUDY CHAIR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

January 31, 2008

First Posted

February 13, 2008

Study Start

January 1, 2007

Primary Completion

August 1, 2009

Last Updated

August 6, 2014

Results First Posted

July 19, 2011

Record last verified: 2014-08

Locations