NCT00614536

Brief Summary

The purpose of this observational study is to examine RSI (Reflux Symptom Index) and RFS (Reflux Finding Score) by treatment period before and after rabeprazole treatment in LaryngoPharyngeal Reflux Disease(LPRD) patients.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,142

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2007

Shorter than P25 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2007

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

January 24, 2008

Completed
20 days until next milestone

First Posted

Study publicly available on registry

February 13, 2008

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2008

Completed
Last Updated

April 28, 2014

Status Verified

April 1, 2014

Enrollment Period

7 months

First QC Date

January 24, 2008

Last Update Submit

April 24, 2014

Conditions

Keywords

Reflux Symptom IndexReflux Finding ScoreRabeprazoleLaryngoPharyngeal Reflux DiseaseGastroEsophageal Reflux Disease

Outcome Measures

Primary Outcomes (1)

  • The change from baseline in RSI and RFS score during LPRD treatment period,

    12 weeks

Secondary Outcomes (2)

  • Regional difference in distribution of symptoms and lesions, and in severity

    12 weeks

  • LRPD treatment period with rabaprazole sodium

    12 weeks

Study Arms (1)

001

Drug: Rabeprazole Sodium

Interventions

10mg - 20mg tablet once or twice daily for 12weeks

001

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Among the patients who visit the department of otolaryngology with suspicious laryngopharyngeal reflux ; Patients who need rabeprazole treatment according to the doctor's discretion

You may qualify if:

  • Patients who visit the department of otolaryngology with suspicious laryngopharyngeal reflux
  • Patients who need rabeprazole treatment according to the doctor's discretion
  • Patients who have signed an informed consent document indicating that they understand the purpose of and procedures required for the observational study and they agree to provide their information

You may not qualify if:

  • Patients who took rabeprazole within the past one month
  • Patients who are hypersensitive to any of rabeprazole or benzimidazole
  • Patients with severe hepatic impairment
  • Pregnant or lactating women

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Gastroesophageal RefluxPharyngeal Diseases

Interventions

Rabeprazole

Condition Hierarchy (Ancestors)

Esophageal Motility DisordersDeglutition DisordersEsophageal DiseasesGastrointestinal DiseasesDigestive System DiseasesStomatognathic DiseasesOtorhinolaryngologic Diseases

Intervention Hierarchy (Ancestors)

2-PyridinylmethylsulfinylbenzimidazolesSulfoxidesSulfur CompoundsOrganic ChemicalsPyridinesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsBenzimidazolesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-Ring

Study Officials

  • Janssen Korea, Ltd. Clinical Trial

    Janssen Korea, Ltd.

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 24, 2008

First Posted

February 13, 2008

Study Start

September 1, 2007

Primary Completion

April 1, 2008

Study Completion

April 1, 2008

Last Updated

April 28, 2014

Record last verified: 2014-04