Mechanisms of the Effect of Physical Activity on the Adaptation to a High-Fat Diet

NCT00611117 | Completed DMC

• 2 other identifiers: PBRC 2701758-6535-5-071
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

The study is designed to determine the effect of high physical activity level vs. low physical activity level on the adaptation to a high fat diet.

Conditions

Healthy

Keywords

adaptation to high fat diet; activity; exercise

Outcome Measures

Primary Outcomes (1)

• To determine the effects of a high fat diet [at both low and high physical activity] on • Sk muscle PGC1α and PDK4 mRNA and protein • Glucose oxidation • Fatty acid oxidation • Hepatic and skeletal muscle lipid • VO2 max • Mitochondr

  One Year

Study Arms (2)

1

EXPERIMENTAL

High intensity exercise and high fat diet

Other: Physical Activity Level

2

EXPERIMENTAL

Low intensity exercise and high fat diet

Other: Physical Activity Level

Interventions

Physical Activity Level OTHER

High vs. low physical activity during a high fat diet consumption.

1; 2

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Both genders and all races will be invited to participate
• BMI \> 19 and \< 35 kg/m2
• Age 18-35
• Women will be asked to participate in the follicular phase of the menstrual cycle as determined by menstrual history and a negative pregnancy test will be recorded prior to participation
• Willing and able to walk on a treadmill at a pace of 3 mph at 3%grade for 3-4 hours/day for 3 consecutive days
• Willing to eat only and all foods provided by Pennington for 9 days on 2 occasions (18 days)
• Willing to stop alcohol consumption for the duration of the study
• Able come to Pennington for meals and tests for 20 days 12 of these inpatient.

You may not qualify if:

• Significant renal, hepatic, endocrine, pulmonary, cardiac or hematological disease (for the consent form you will have to use kidney, liver, etc )
• You abuse alcohol or illegal drugs or are unable to avoid alcohol or caffeine prior to testing
• Smokers
• Unable or unlikely to eat all and only food provided by the PBRC metabolic kitchen.
• Pregnant or planning to become pregnant
• Corticosteroid use in previous two months
• Chronic use of anti-diabetic, anti-hypertensive, or other medications known to affect fat metabolism
• Use of Depo-Provera, hormone implants or estrogen replacement therapy
• Irregular menstrual cycles
• Post-menopausal women
• Weight gain or loss of \> 3kg in the last 6 months
• Unable or unwilling to perform treadmill walking at the required speed and incline to achieve 1.8\*RMR
• History or family history of blood clots deep vein thrombosis or pulmonary embolism)
• Poor circulation, bypass operation on legs, blood coagulation disorders, diagnosed peripheral arterial or vascular disease, cramping pain in your muscle during exercise or nerve damage in your legs.
• You had major surgery on the abdomen, pelvis or legs within previous 3 months.

Sponsors & Collaborators

• Pennington Biomedical Research Center: lead
• University of Washington: collaborator

Study Sites (1)

Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Steven Smith

  Pennington Biomedical Research Center

  PRINCIPAL INVESTIGATOR

• George Bray

  Pennington Biomedical Research Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: CARE PROVIDER
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 28, 2008
• First Posted: February 8, 2008
• Study Start: May 1, 2007
• Primary Completion: March 1, 2009
• Study Completion: June 1, 2020
• Last Updated: September 21, 2022

Record last verified: 2016-01

Locations

US (1)