Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)
1 other identifier
observational
57
1 country
1
Brief Summary
Sturge-Weber Syndrome (SWS) is a neurological disorder characterized at birth by seizures and a large port-wine stain birthmark on the forehead and upper eyelid of one side of the face. SWS is also accompanied by an increased pressure within the eye (glaucoma) which can develop very early in life. Glaucoma represents a group of ocular disorders that are characterized by the loss of retinal ganglion cells and their axons, damage to the optic nerve, and gradual loss of visual field. Recently, several studies provided evidence that there is a potential role of the immune system in the pathogenesis of glaucoma. These findings suggest that there might be changes in systemic humoral immunity possibly underlying the optic neuropathy in at least some glaucoma patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jul 2007
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2007
CompletedFirst Submitted
Initial submission to the registry
January 25, 2008
CompletedFirst Posted
Study publicly available on registry
February 8, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2008
CompletedOctober 20, 2022
October 1, 2022
Same day
January 25, 2008
October 19, 2022
Conditions
Study Arms (1)
blood sample tear drop sample
blood sample tear drop sample
Interventions
Eligibility Criteria
community sample
You may qualify if:
- Male and female volunteers with SWS of all ages
You may not qualify if:
- Volunteers without SWS
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of California, Irvinelead
- Mainz Universitycollaborator
Study Sites (1)
Beckman Laser Institute Medical clinic
Irvine, California, 92612, United States
Biospecimen
blood sample tear drop sample
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
John S Nelson, M.D,PhD
Beckman Laser Institute University of California Irvine
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- J.S.Nelson, MD,PhD,Professor of Surgery and Biomedical Engineering
Study Record Dates
First Submitted
January 25, 2008
First Posted
February 8, 2008
Study Start
July 1, 2007
Primary Completion
July 1, 2007
Study Completion
June 1, 2008
Last Updated
October 20, 2022
Record last verified: 2022-10