Association Between Cytokines and Severity of Respiratory Syncytial Virus (RSV)-Induced Illness in the Elderly

NCT00609635 | Completed

• 1 other identifier: Adult RSV RC# 4212
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This research study involves studying the genes that may affect how ill you become during respiratory infection with respiratory syncytial virus (RSV). RSV is a virus that often causes common colds. Cytokines are chemicals that are naturally made by your body. Cytokine levels are increased in some people when they have common colds or wheezing caused by respiratory syncytial virus (RSV). The purpose of this study is to study the genes that may control cytokine levels during infection with RSV in the elderly population.

Conditions

Respiratory Syncytial Virus Infections

Keywords

Respiratory; RSV-induced respiratory illness

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

inpatient or outpatient subjects with respiratory illnesses potentially caused by RSV

You may qualify if:

• Subjects \> 65 years of age diagnosed with RSV-induced respiratory illness
• Diagnosis (based upon ICD-9-CM codes) for pneumonia, upper respiratory illness, bronchitis, COPD, asthma, viral illness, or congestive heart failure (CHF)
• Willing to sign informed consent.

You may not qualify if:

• Not willing to sign informed consent.
• Subjects less that 65 years of age
• Subjects not diagnosed with a respiratory illness

Sponsors & Collaborators

• West Penn Allegheny Health System: lead
• American Academy of Allergy, Asthma, and Immunology: collaborator

Study Sites (1)

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

A buccal brushing (cells collected from the inside of the cheek) will be collected and stored for DNA analysis.

MeSH Terms

Conditions

Respiratory Syncytial Virus Infections

Condition Hierarchy (Ancestors)

Pneumovirus Infections; Paramyxoviridae Infections; Mononegavirales Infections; RNA Virus Infections; Virus Diseases; Infections

Study Officials

• Ritu Pabby, MD

  West Penn Allegheny Health System

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 25, 2008
• First Posted: February 7, 2008
• Study Start: November 1, 2007
• Primary Completion: April 1, 2009
• Study Completion: April 1, 2009
• Last Updated: April 6, 2009

Record last verified: 2009-04

Locations

US (1)