Acclimatization Mechanisms During Ascent to 7500m
2 other identifiers
interventional
37
0 countries
N/A
Brief Summary
The trial evaluates the role of ascent protocol on acute mountain sickness and cardio-respiratory physiology during an ascent to Muztagh Ata (7546m). Two groups of mountaineers ascend with different acclimatization time to the summit. The prevalence and severity of symptoms of acute mountain sickness are evaluated along with physiologic variables.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Mar 2005
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2005
CompletedFirst Submitted
Initial submission to the registry
January 15, 2008
CompletedFirst Posted
Study publicly available on registry
January 28, 2008
CompletedMay 20, 2014
May 1, 2014
9 months
January 15, 2008
May 18, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
acute mountain sickness
during ascent
Secondary Outcomes (1)
mountaineering success, oxygen saturation, breathing pattern
during ascent
Study Arms (2)
1
EXPERIMENTALfast ascent
2
ACTIVE COMPARATORslow ascent
Interventions
Eligibility Criteria
You may qualify if:
- Healthy, physically fit subject
- Mountaineering experience
You may not qualify if:
- Any type of cardiac or respiratory disease
- Regular intake of any medication
- History of high altitude pulmonary oedema
- Severe acute mountain sickness at altitudes below 3500m or high altitude cerebral oedema.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Zurichlead
- Swiss National Science Foundationcollaborator
Related Publications (4)
Bloch KE, Latshang TD, Turk AJ, Hess T, Hefti U, Merz TM, Bosch MM, Barthelmes D, Hefti JP, Maggiorini M, Schoch OD. Nocturnal periodic breathing during acclimatization at very high altitude at Mount Muztagh Ata (7,546 m). Am J Respir Crit Care Med. 2010 Aug 15;182(4):562-8. doi: 10.1164/rccm.200911-1694OC. Epub 2010 May 4.
PMID: 20442435BACKGROUNDGarde A, Giraldo BF, Jane R, Latshang TD, Turk AJ, Hess T, Bosch MM, Barthelmes D, Hefti JP, Maggiorini M, Hefti U, Merz TM, Schoch OD, Bloch KE. Periodic breathing during ascent to extreme altitude quantified by spectral analysis of the respiratory volume signal. Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:707-10. doi: 10.1109/EMBC.2012.6346029.
PMID: 23365990BACKGROUNDLatshang TD, Turk AJ, Hess T, Schoch OD, Bosch MM, Barthelmes D, Merz TM, Hefti U, Hefti JP, Maggiorini M, Bloch KE. Acclimatization improves submaximal exercise economy at 5533 m. Scand J Med Sci Sports. 2013 Aug;23(4):458-67. doi: 10.1111/j.1600-0838.2011.01403.x. Epub 2011 Nov 3.
PMID: 22093058BACKGROUNDBloch KE, Turk AJ, Maggiorini M, Hess T, Merz T, Bosch MM, Barthelmes D, Hefti U, Pichler J, Senn O, Schoch OD. Effect of ascent protocol on acute mountain sickness and success at Muztagh Ata, 7546 m. High Alt Med Biol. 2009 Spring;10(1):25-32. doi: 10.1089/ham.2008.1043.
PMID: 19326598RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Konrad E Bloch, MD
Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
January 15, 2008
First Posted
January 28, 2008
Study Start
March 1, 2005
Primary Completion
December 1, 2005
Study Completion
December 1, 2005
Last Updated
May 20, 2014
Record last verified: 2014-05