NCT00596843

Brief Summary

The purpose of this study is to determine if a 6-session motivational interviewing intervention is more effective than a 6-session educational intervention at reducing behaviors that may lead to infection, transmission, and progression of HIV and hepatitis C among out of treatment injecting drug users.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
851

participants targeted

Target at P75+ for phase_3 hiv

Timeline
Completed

Started Sep 2003

Typical duration for phase_3 hiv

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2003

Completed
3.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2006

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2006

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

January 7, 2008

Completed
10 days until next milestone

First Posted

Study publicly available on registry

January 17, 2008

Completed
Last Updated

March 1, 2017

Status Verified

November 1, 2008

Enrollment Period

3.2 years

First QC Date

January 7, 2008

Last Update Submit

February 28, 2017

Conditions

Outcome Measures

Primary Outcomes (1)

  • Reduction/cessation of alcohol use

    6-months and 12-months

Secondary Outcomes (2)

  • Reductions in direct and indirect needle and syringe sharing

    6-months and 12-months

  • Reductions in unprotected sexual behavior

    6-months and 12-months

Study Arms (2)

1

EXPERIMENTAL

Motivational intervention

Behavioral: Motivational interviewing

2

ACTIVE COMPARATOR

Educational intervention

Behavioral: Educational intervention

Interventions

6 one-on-one individual sessions lasting from 30 minutes to 1-hour each

1

6 1-hour sessions. 2 sessions are delivered by an interventionist and 4 sessions are delivered as videos

2

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • minimum age of 18 years injected illicit drugs within last 30 days

You may not qualify if:

  • participated in formal substance treatment in last 30 days

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

RTI International Field Site

Durham, North Carolina, United States

Location

Related Publications (1)

  • Zule WA, Costenbader EC, Coomes CM, Wechsberg WM. Effects of a hepatitis C virus educational intervention or a motivational intervention on alcohol use, injection drug use, and sexual risk behaviors among injection drug users. Am J Public Health. 2009 Apr;99 Suppl 1(Suppl 1):S180-6. doi: 10.2105/AJPH.2007.126854. Epub 2009 Feb 12.

MeSH Terms

Conditions

Hepatitis C

Interventions

Motivational InterviewingEarly Intervention, Educational

Condition Hierarchy (Ancestors)

Blood-Borne InfectionsCommunicable DiseasesInfectionsHepatitis, Viral, HumanVirus DiseasesFlaviviridae InfectionsRNA Virus InfectionsHepatitisLiver DiseasesDigestive System Diseases

Intervention Hierarchy (Ancestors)

Directive CounselingCounselingMental Health ServicesBehavioral Disciplines and ActivitiesHealth ServicesHealth Care Facilities Workforce and ServicesChild Health ServicesCommunity Health ServicesPreventive Health Services

Study Officials

  • William A. Zule, Dr.P.H.

    RTI International

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 7, 2008

First Posted

January 17, 2008

Study Start

September 1, 2003

Primary Completion

November 1, 2006

Study Completion

November 1, 2006

Last Updated

March 1, 2017

Record last verified: 2008-11

Locations