Systemic Reactions to Allergen Immunotherapy Amd Skin Testing

NCT00594802 | Completed

• 1 other identifier: systemic reaction protocol
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Allergy skin tests and allergen immunotherapy are common procedures for both the diagnosis and treatment of atopic diseases. Allergen immunotherapy has proved to be effective in reducing the symptoms of allergic rhinitis and asthma1-2. Despite its clinical benefit, there is risk of systemic reactions associated with these procedures. The systemic reaction rate to skin testing for aeroallergens is significant lower than the rate of reactions to immunotherapy, but it is not negligible. Lin et al reported only 2 patients who had systemic allergic reactions to skin testing for respiratory allergies in 10,400 patients tested.3 They determined the overall risk of inducing anaphylactic reactions by skin testing to be less than 0.02% and other studies have produced similar results.4-5 The rate of systemic reactions to skin testing is likely underscored. Thompson et. al reported a systemic reaction rate of 6% of patients receiving skin testing.6 It is important to recognize the risk of systemic reactions seeing skin testing is commonly done. It is also imperative to recognize the treatments for these reactions to prevent progression. Hypothesis The systemic reaction rate to allergen immunotherapy and skin testing to aeroallergens is higher than previously reported. Biphasic anaphylactic reactions rarely occur with allergen immunotherapy and skin testing.

Conditions

SYSTEMIC REACTION

Keywords

ALLERGIC REACTION

Outcome Measures

Primary Outcomes (1)

• This is a prospective observational study of patients who are having either skin testing or allergen immunotherapy for the diagnosis or treatment of allergic rhinitis, conjunctivitis, and/or asthma.

Study Arms (1)

CHART REVIEW ONLY

CHART REVIEW OF PATIENTS WITH SYSTEMIC REACTIONS

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Male and female subjects who are receiving skin testing or allergen immunotherapy from one allergy practice.

You may qualify if:

• Male and female subjects who are receiving skin testing or allergen immunotherapy from one allergy practice.

You may not qualify if:

• NON Male and female subjects who are receiving skin testing or allergen immunotherapy from one allergy practice.

Sponsors & Collaborators

• University of South Florida: lead

Study Sites (1)

USF

Tampa, Florida, 33613, United States

Location

Related Publications (1)

• Bagg A, Chacko T, Lockey R. Reactions to prick and intradermal skin tests. Ann Allergy Asthma Immunol. 2009 May;102(5):400-2. doi: 10.1016/S1081-1206(10)60511-X.

  PMID: 19492661 DERIVED

MeSH Terms

Conditions

Hypersensitivity

Condition Hierarchy (Ancestors)

Immune System Diseases

Study Officials

• RICHARD F LOCKEY, MD

  USF DIRECTOR OF ALLERGY AND IMMUNOLOGY

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 4, 2008
• First Posted: January 16, 2008
• Study Start: August 1, 2006
• Primary Completion: June 1, 2007
• Study Completion: June 1, 2007
• Last Updated: August 9, 2010

Record last verified: 2008-07

Locations

US (1)