Risk Factors for Adult-Onset Brain Tumors

NCT00592865 | Terminated

• 1 other identifier: 030917
• Study Type: observational
• Target: 850
• Locations: 1 country
• Sites: 5

Brief Summary

Study Objective: Brain tumors are poorly understood. The purpose of this research is to examine whether factors in lifestyle play a role in brain tumor development. The study will also investigate the contribution of inherited susceptibility to the risk of brain cancer. By gaining a better understanding of these influences, the investigators hope to learn how to prevent brain tumors in future generations, and to develop more effective strategies for treatment. Study Protocol: This is a case-control investigation. Persons affected with a brain tumor are compared to unaffected persons on previous medical history, diet and other factors. Those enrolled in the study will participate in an interview on general background, diet, medical history and lifestyle, and will provide a sample of DNA, clippings of your toenails, and a tap water sample from your home. All procedures are performed in the clinic or through the mail. 'Cases': Cases eligible for the study are persons with a recent diagnosis of a primary brain tumor (glioma or meningioma), at least 18 years of age. 'Controls': Controls in the study are non-family members of patients, similar in age and of the same gender. Suitable controls include in-laws, friends, neighbors and co-workers.

Conditions

Brain Neoplasm, Primary; Brain Neoplasms, Malignant; Brain Neoplasms, Benign

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

"Case" subjects will be identified from the patients referred to neurology/neurosurgery clinics. Cases, when enrolled in the study, will be asked to identify potential "controls" by providing the name and phone number of the same-sex in-law nearest in age to the case and/or the name of a same-sex friend will also be sought.

You may qualify if:

• Case: Incident primary glioma or meningioma of any stage, diagnosed within 4 months.
• Control: non-blood relative, friend, co-worker of same gender as case
• Aged 18 and older; either gender; any race

You may not qualify if:

• None

Sponsors & Collaborators

• Vanderbilt University Medical Center: lead
• H. Lee Moffitt Cancer Center and Research Institute: collaborator
• Kentuckiana Cancer Institute: collaborator
• Emory University: collaborator
• University of Alabama at Birmingham: collaborator

Study Sites (5)

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

Location

H. Lee Moffitt Cancer Center

Tampa, Florida, 33612, United States

Location

Emory University

Atlanta, Georgia, 30322, United States

Location

Kentuckaina Cancer Institute

Louisville, Kentucky, 40202, United States

Location

Vanderbilt University Medical Center, Department of Neurological Surgery

Nashville, Tennessee, 37232, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Mouthwash and salvia samples. Toenail samples are also collected.

MeSH Terms

Conditions

Brain Neoplasms

Condition Hierarchy (Ancestors)

Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Kathleen M. Egan, DSc

  H. Lee Moffitt Cancer Center

  PRINCIPAL INVESTIGATOR

• Reid C. Thompson, MD

  Vanderbilt University Medical Center

  PRINCIPAL INVESTIGATOR

• Renato V. LaRocca, MD

  Kentuckiana Cancer Center

  PRINCIPAL INVESTIGATOR

• Jeffrey Olson, MD

  Emory University

  PRINCIPAL INVESTIGATOR

• Burt Nabors, MD

  University of Alabama at Birmingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department Chair and Professor, Neurological Surgery

Study Record Dates

• First Submitted: January 7, 2008
• First Posted: January 14, 2008
• Study Start: October 1, 2003
• Primary Completion: January 1, 2015
• Study Completion: January 1, 2015
• Last Updated: February 21, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (5)