Transfer of Grasp Control Across Hands After Stroke

NCT00589368 | Completed

• 2 other identifiers: 04-0585K23HD049472
• Study Type: observational
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine if the strong hand can assist in the recovery of muscle function in the weak hand after a stroke.

Conditions

Stroke With Hemiparesis

Keywords

Brain Infarction; pathology; physiopathology; psychology; rehabilitation; Fingers; Grasp; Functional Laterality; Hand; Strength; Neuronal Plasticity; Psychomotor Performance; Biomechanis; Touch; Weight-Bearing

Outcome Measures

Primary Outcomes (1)

• Difference in peak load force rates for grasping a light and a heavy weight object as measured using a custom made object with 6 dof force sensors.

  immediately post-intervention

Secondary Outcomes (1)

• Timing and magnitude of motor unit recruitment as measured by quantitative EMG of the grasping and lifting muscles.

  immediately post-intervention

Study Arms (2)

1

stroke group

Behavioral: Transfer of grasp control across hands

2

control group

Behavioral: Transfer of grasp control across hands

Interventions

Transfer of grasp control across hands BEHAVIORAL

transfer of planning and execution of grasp across hands in terms of its effect on fingertip forces, and the timing and magnitude of muscle contraction in patients with hemiparesis and healthy controls

1; 2

Eligibility Criteria

• Age: 21 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects with stroke will be recruited from the inpatient and outpatient Rehabilitation units at the Mount Sinai Medical Center and from referrals by community rehabilitation physicians and neurologists. Control subjects will be recruited by public advertisement in the New York City area. There are no exclusions based on gender or ethnic groups.

You may qualify if:

• Previously right-handed subjects with hemiparesis and complaints of unilateral hand dysfunction during grasping resulting from a single unilateral cerebral infarct in the MCA territory affecting either the right or the left side of the brain at least 3 months prior to data collection
• Previously right-handed healthy control subjects age-matched to the stroke patients
• All subjects must have the ability to reach, grasp and lift the test object with both extremities (stroke patients with the impaired extremity as well) and complete the experimental protocol as assessed by the PI.
• All subjects must score \> 24 on the Folstein's mini-mental exam to screen out significant cognitive dysfunction
• Subjects must obtain MRI or CT scan images of their brain taken since their stroke, or be willing to have a structural MRI or CT scan taken as part of this research study.

You may not qualify if:

• Presence of clinically significant visual deficits, aphasia, neglect, or apraxia as determined by clinical neurologic examination that may interfere with the research protocol
• Presence of sensory deficits in control subjects and in the non-involved hand of stroke subjects on testing of two-point discrimination
• History of surgery or other significant injury to the upper extremities
• Botulinum toxin injections in the upper extremity musculature in the three months prior to enrollment in the study.
• Current treatment with intrathecal baclofen
• Previous neurological illness such as head trauma, prior stroke, epilepsy, demyelinating disease
• Complicating medical problems such as uncontrolled, diabetes with polyneuropathy, severe renal, cardiac or pulmonary disease, or any other severe concurrent medical problem that will interfere with obtaining reliable results.

Sponsors & Collaborators

• NYU Langone Health: lead
• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): collaborator

Study Sites (1)

Rusk Institute of Rehabilitation Medicine

New York, New York, 10016, United States

Location

MeSH Terms

Conditions

Brain Infarction

Condition Hierarchy (Ancestors)

Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke; Vascular Diseases; Cardiovascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Preeti Raghavan, MD

  NYU School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Rehabilitation Medicine

Study Record Dates

• First Submitted: December 24, 2007
• First Posted: January 9, 2008
• Study Start: May 1, 2006
• Primary Completion: May 1, 2012
• Study Completion: May 1, 2012
• Last Updated: October 8, 2012

Record last verified: 2012-10

Locations

US (1)