NCT00586638

Brief Summary

Control processes are classes of brain activity that initiate, coordinate, synchronize, and regulate elemental cognitive functions for the conduct of goal-directed behavior. The proposed research investigates whether exposure to a computer-based training protocol designed to enhance cognitive control processes will improve cognitive performance in healthy older adults.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Dec 2007

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2007

Completed
19 days until next milestone

First Submitted

Initial submission to the registry

December 20, 2007

Completed
15 days until next milestone

First Posted

Study publicly available on registry

January 4, 2008

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2010

Completed
Last Updated

August 5, 2015

Status Verified

August 1, 2015

Enrollment Period

2.2 years

First QC Date

December 20, 2007

Last Update Submit

August 3, 2015

Conditions

Keywords

cognitioncognition disordersexecutive functioncognitive controlattentional controlbiomedical enhancementcognitive enhancementcomputerizedcomputer-basedvideo game

Outcome Measures

Primary Outcomes (2)

  • Neuropsychological testing

    Week 1, 12, 24

  • Cognitive-experimental tasks

    Week 1, 6, 12, 24

Study Arms (3)

1

EXPERIMENTAL

Video Game play with training strategy

Behavioral: Video game based training

2

ACTIVE COMPARATOR

Video game play without training strategy

Behavioral: Video game based training

3

NO INTERVENTION

Minimal contact control

Interventions

36 one-hour sessions over 12 weeks

12

Eligibility Criteria

Age60 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age 60-75
  • Willingness to adhere to training protocol
  • Adequate English proficiency

You may not qualify if:

  • Known history of cognitive impairment, dementia, stroke, seizure disorder, or other neuropsychiatric condition judged to impact cognitive performance
  • Taking medications known to influence cognitive performance
  • Sensory (e.g. visual, auditory) or physical (e.g. severe arthritic, orthopedic, neurologic) impairment incompatible with use of a standard computer workstation.
  • Enrolled in a concurrent study that could affect the outcome of this study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Columbia University Medical Center

New York, New York, 10032, United States

Location

Related Publications (2)

  • Blumen HM, Gopher D, Steinerman JR, Stern Y. Training cognitive control in older adults with the space fortress game: the role of training instructions and basic motor ability. Front Aging Neurosci. 2010 Nov 11;2:145. doi: 10.3389/fnagi.2010.00145. eCollection 2010.

  • Stern Y, Blumen HM, Rich LW, Richards A, Herzberg G, Gopher D. Space Fortress game training and executive control in older adults: a pilot intervention. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2011 Nov;18(6):653-77. doi: 10.1080/13825585.2011.613450. Epub 2011 Oct 12.

MeSH Terms

Conditions

Neurologic ManifestationsNeurobehavioral ManifestationsCognition Disorders

Condition Hierarchy (Ancestors)

Nervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsNeurocognitive DisordersMental Disorders

Study Officials

  • Yaakov Stern, Ph.D.

    Columbia University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Clinical, Department of Neurology Administration

Study Record Dates

First Submitted

December 20, 2007

First Posted

January 4, 2008

Study Start

December 1, 2007

Primary Completion

February 1, 2010

Study Completion

February 1, 2010

Last Updated

August 5, 2015

Record last verified: 2015-08

Locations