NCT00582335

Brief Summary

The purpose of this study is to define new genes for family risks of developing colon cancer.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
337

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 1998

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 10, 1998

Completed
9.9 years until next milestone

First Submitted

Initial submission to the registry

December 21, 2007

Completed
7 days until next milestone

First Posted

Study publicly available on registry

December 28, 2007

Completed
14 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 17, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 17, 2021

Completed
Last Updated

December 21, 2021

Status Verified

December 1, 2021

Enrollment Period

23.9 years

First QC Date

December 21, 2007

Last Update Submit

December 20, 2021

Conditions

Colorectal Cancer

Keywords

Colorectal cancerGenetic testingGenetic mutations

Outcome Measures

Primary Outcomes (1)

  • Evidence of mutations in selected candidate genes

    10 years 10 months

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

families seen at MSKCC with at least two first-degree relatives affected with colorectal cancer

You may qualify if:

  • Age 18 years or greater
  • Able to provide informed consent

You may not qualify if:

  • Age less than 18 years
  • Family not at increased risk for familial colorectal cancer (see Section 4.1)
  • Family with a hereditary polyposis syndrome (e.g. classic FAP)
  • Not able to provide informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

Location

Related Links

Biospecimen

Retention: SAMPLES WITH DNA

Blood Tissue (tumor)

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesColonic DiseasesIntestinal DiseasesRectal Diseases

Study Officials

  • Kenneth Offit, MD

    Memorial Sloan Kettering Cancer Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
FAMILY BASED
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 21, 2007

First Posted

December 28, 2007

Study Start

February 10, 1998

Primary Completion

December 17, 2021

Study Completion

December 17, 2021

Last Updated

December 21, 2021

Record last verified: 2021-12

Locations

US(1)