Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging

NCT00579618 | Completed

• 1 other identifier: 06-102
• Study Type: observational
• Target: 53
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to help us learn more about the roles of genes in cancers. Genes are short pieces of DNA which determine the inherited characteristics that distinguish one individual from another. This study will look at how some genes might raise or lower the chance some people may develop cancer. The sample collection will help generate the materials needed for this study.

Conditions

Non-cancer Affected Volunteers

Keywords

non-cancer affected volunteers; aged 60 years or older

Outcome Measures

Primary Outcomes (1)

• obtain saliva or blood from non-cancer volunteers, 60 years or older to carry out anonymous genetic epidemiology studies related to resistance to cancer in elderly.

  conclusion of the study

Secondary Outcomes (1)

• samples perform high density genomic scans & candid gene studies carriers specif BRCA found mutat who haven't been affect by breast cancer & old than 60 find genetic cofactor may modify a predispo breast ca confer by germline mutation in BRCA1 & BRCA2.

  conclusion of the study

Interventions

Saliva or Blood samples OTHER

Extracting sample of saliva or blood only once.

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Nursing homes, senior centers, health fairs or other community organizations.

You may qualify if:

• Eligible subjects must be non-cancer affected volunteers of either gender who are 60 years of age or older at the time of saliva/blood donation.
• Subjects will self-identify religion and country of origin of grandparents.
• Volunteers will have (by self report) no history of cancer other than nonmelanoma skin cancer. It is recognized that there may be some errors in self report, however, the literature reports a very low error rate for self reported disease reporting for cancer as assessed by interview.

You may not qualify if:

• Subjects with mental impairment will be excluded from this study.

Sponsors & Collaborators

• Memorial Sloan Kettering Cancer Center: lead
• Susan G. Komen Breast Cancer Foundation: collaborator
• Beth Abraham: collaborator
• Gurwin Jewish Nursing & Rehabilitation Center: collaborator
• Hebrew Home at Riverdale: collaborator
• Jewish Home & Hospital Lifecare System: collaborator
• Margaret Tietz Nursing and Rehabilitation Center: collaborator
• Metropolitan Jewish Health System: collaborator
• Northern Services Group: collaborator
• Parker Jewish Institute: collaborator
• Lenox Hill Neighborhood House: collaborator
• JASA at Temple Emanuel of Parkchester Senior Center: collaborator
• Van Cortlandt Village Senior Center: collaborator

Study Sites (1)

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

Location

Related Links

• Memorial Sloan Kettering Web Site

Biospecimen

Retention: SAMPLES WITH DNA

Saliva or blood samples

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Kenneth Offit, MD, MPH

  Memorial Sloan Kettering Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 20, 2007
• First Posted: December 24, 2007
• Study Start: September 1, 2006
• Primary Completion: July 1, 2017
• Study Completion: July 1, 2017
• Last Updated: July 31, 2017

Record last verified: 2017-07

Locations

US (1)