A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome
3 other identifiers
interventional
340
1 country
9
Brief Summary
The study aims to examine whether the combination of Lopinavir/Ritonavir plus Ribavirin for treatment of severe acute respiratory syndrome (SARS) is superior to placebo.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
9 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 20, 2007
CompletedFirst Posted
Study publicly available on registry
December 21, 2007
CompletedAugust 22, 2013
August 1, 2013
December 20, 2007
August 21, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Development of severe SARS
Any time during the acute illness
Secondary Outcomes (3)
Adverse events
Throughout the illness period
SARS-CoV Viral load
Throughout the illness period
Immunological profile
Throughout the illness period
Interventions
Eligibility Criteria
You may qualify if:
- Male or female over the age of 18 with a diagnosis of SARS and with valid consent will be recruited.
You may not qualify if:
- Subjects with medical conditions that makes the prescription of study medications unsafe are excluded.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (9)
Department of Health
Hong Kong, China
Kowloon Hospital
Hong Kong, China
Prince of Wales Hospital
Hong Kong, China
Princess Margaret Hospital
Hong Kong, China
Queen Mary Hospital
Hong Kong, China
The Chinese University of Hong Kong
Hong Kong, China
The University of Hong Kong
Hong Kong, China
Tuen Mun Hospital
Hong Kong, China
United Christian Hospital
Hong Kong, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Wai Cho Yu, Dr
Department of Medicine & Geriatrics, Princess Margaret Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
Study Record Dates
First Submitted
December 20, 2007
First Posted
December 21, 2007
Last Updated
August 22, 2013
Record last verified: 2013-08