Fertility Preservation by Ovarian and Oocyte Cryopreservation
HFPP
Study That Establishes the Potential of Fertility Preservation in Young Female Patients by Oocyte in Vitro Maturation and Cryopreservation and Ovarian Cortex Cryopreservation and Transplantation
2 other identifiers
interventional
200
1 country
1
Brief Summary
Success rates of cancer treatment have increased significantly resulting in many girls and young women who are treated now and will be cancer survivors. Nevertheless, cancer treatment may result in long term side effects. Damage to the ovaries may result in serious difficulty to become pregnant in the future. The risk of this happening depends, among others upon patient's age, disease and type of treatment she undergoes. Medical research is continuously looking into ways to preserve female fertility by using less toxic protocols. Yet, keeping your eggs outside the body during treatment is an interesting option which as is routine for boys preserving sperm before cancer treatment. This research attempts to freeze eggs either in the ovarian tissue or individually.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2
Started Jan 2000
Longer than P75 for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2000
CompletedFirst Submitted
Initial submission to the registry
December 19, 2007
CompletedFirst Posted
Study publicly available on registry
December 21, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2010
CompletedDecember 21, 2007
January 1, 2002
December 19, 2007
December 19, 2007
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
risks involved in laparoscopic oophorectomy
10 years
Secondary Outcomes (1)
Ability to restore fertility by ovarian cortex transplantation
10 years
Study Arms (1)
OCCT
ACTIVE COMPARATORPatients referred to ovarian cryopreservation.
Interventions
Patients will undergo laparoscopic oophorectomy, aspiration of oocytes and maturation followed by cryopreservation. In case of ovarian failure and approval by treating physicians, restoration of fertility will be attempted by thawing of oocytes or by transplantation of ovarian cortex to induce ovulation and obtain oocytes for fertilization and embryo transfer.
Eligibility Criteria
You may qualify if:
- patients before chemotherapy with significant risk to future fertility
You may not qualify if:
- high operative risk
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hadassah University Hospital
Jerusalem, 91128, Israel
Related Publications (1)
Revel A, Koler M, Simon A, Lewin A, Laufer N, Safran A. Oocyte collection during cryopreservation of the ovarian cortex. Fertil Steril. 2003 May;79(5):1237-9. doi: 10.1016/s0015-0282(02)04963-4. No abstract available.
PMID: 12738527RESULT
Study Officials
- PRINCIPAL INVESTIGATOR
Ariel Revel, MD
Hadassah university hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
December 19, 2007
First Posted
December 21, 2007
Study Start
January 1, 2000
Study Completion
January 1, 2010
Last Updated
December 21, 2007
Record last verified: 2002-01