NCT00572884

Completed

Metabolism of the Insecticide Permethrin

University of California, Davis Source

Compare

Other study identifiers

Sponsor study identifier

200311123-8

Secondary identifiers

DAMD17-01-1-0769

P42ES004699

NIH

Study Type

interventional

Actual enrollment (reported)

6

Locations

1 country

Sites

1

Timeline

Study Start

February 2006

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

Not reported

Date not reported

Study Completion

November 2007

Actual (reported)

Brief Summary

Military personnel are exposed to the insecticide permethrin when using the DOD Insect Repellent System. A urinary metabolite of permethrin that is in high abundance and is relatively stable may be an ideal biomarker of exposure to this pesticide. Monitoring such a biomarker can prevent over-exposure. The objectives are to identify the most abundant human urinary metabolite following dermal exposure; to utilize this information to develop rapid laboratory-based and field portable methods to monitor the degree of an individual's exposure to permethrin.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 6 participants
Study completion date: November 2007
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
February 2006
Date type not reported
This date has not been verified as actual or estimated.
Study Completion
November 2007
Actual (reported)
First Submitted
December 11, 2007
Actual (reported)
First Posted
December 13, 2007
Actual (reported)

Last Updated: December 13, 2007
Status Verified: December 2007
Last Update Submitted: December 11, 2007

Conditions

Metabolism Pharmacokinetics

Keywords

permethrinpyrethroidpharmacokineticsmetabolismaccelerator mass spectrometryhuman exposure

Outcome Measures

Primary Outcomes (1)

Concentration of individual metabolites in urine
192 hours

Secondary Outcomes (3)

total carbon-14 in serum
192 hours
Total carbon-14 in saliva
192 hours
Total carbon-14 in urine samples
192 hours

Interventions

permethrin insecticideOther

25 mg neat carbon-14 labelled permethrin applied dermally in isopropyl alcohol, once for 8 hours containing 1 microcurie of carbon-14

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 50 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64)

You may qualify if:

self-report healthy adult men and premenopausal women

You may not qualify if:

Sponsors & Collaborators

U.S. Army Medical Research and Development Command
US federal agencycollaborator
University of California, Davis
Otherlead

Study Sites (1)

CTSC Research Center

Mather, California, 95655, United States

Study Officials

Bruce D Hammock, PhD
University of California, Davis
PRINCIPAL INVESTIGATOR

Enrollment

6 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: BASIC SCIENCE
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER

Study Record Dates

First Submitted

December 11, 2007

First Posted

December 13, 2007

Study Start

February 2006

Date type not reported

This date has not been verified as actual or estimated.

NCT01082146

RI-AME Study OF [ISOTHIAZOLYL-3-14C]-LURASIDONE

Phase 1Completed

NCT00855049

A Randomized Crossover Study to Determine the Pharmacokinetics of Intranasally Administered Acetaminophen in Healthy Adults

Not ApplicableWithdrawn

NCT01041820

Critical Periods of Exercise

Not ApplicableCompleted

NCT04281407

Impact of Probiotics on Drug, Vitamin, and Hormone Metabolism

Not ApplicableUnknown

NCT01905722

Development of Novel Therapies for NIDDM

Not ApplicableCompleted

NCT06407050

Duration of Physical Inactivity and Postprandial Lipid Metabolism

Not ApplicableCompleted

unusual alcohol, drug, cigarette use for last 3 years

unusual exercise program for last 3 years

under the care of a physician for a disease

participated in any radioactive drug study

pregnant

lactating

people who rely more on their arm due to illness or injury

people with neurological or musculoskeletal diseases

use of permethrin in the last 6 months

people who apply pesticides as their primary occupation

Contact the study team to confirm eligibility.

Study Completion

November 2007

Actual (reported)

Last Updated

December 13, 2007

Record last verified: 2007-12

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT00572884
Data provider: ClinicalTrials.gov
Source updated: 2007-12-13
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:22:10 UTC

Locations

US(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (3)

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Enrollment

Study Design

Study Record Dates

Source record

Locations