Effect of Central Corneal Thickness On IOP Using Various Tonometers

NCT00570791 | Completed

• 1 other identifier: 0441-04-FB
• Study Type: observational
• Target: 166
• Locations: 1 country
• Sites: 2

Brief Summary

The primary purpose of this study is to evaluate the effects of ocular physical properties on intraocular pressure (IOP) measurements in eyes with healthy corneas using the following instruments to measure IOP: Goldmann applanation tonometer, pneumotonometer, ocular blood flow pneumotonometer, Tono-Pen, Pascal Dynamic Contour Tonometer and the Schiotz Tonometer. Ocular physical properties to be evaluated are:varying (CCT), corneal curvature (CC), axial length, anterior chamber depth and scleral rigidity. The secondary purpose of this is to determine if there is a correlation between CCT and other ocular properties, and which instruments that measure these other ocular properties are most affected by CCT.

Conditions

Intraocular Pressure

Keywords

Cornea; Tonometers; Goldmann applanation; Tonopen; Shiotz; Pneumatonometer

Outcome Measures

Primary Outcomes (1)

• Eye pressure

  Measured pressure in participants' eyes with six different tonometers

  one - two hours

Study Arms (2)

Effect of age on intraocular pressure

Correlation between age and IOP with GAT compared to other tonometers.

Device: Tonometer

Effect of CCT and IOP

Correlation between CCT and IOP among all tonometers

Device: Tonometer

Interventions

Tonometer DEVICE

Tonometer devices used to measure IOP: Pascal Dynamic Contour Tonometer, Goldman Applanation Tonometer, Tono Pen, Reichart pneumatonometer, Langham Ocular Blood Flow, Schiotz Tonometer and ICare tonometer

Effect of CCT and IOP; Effect of age on intraocular pressure

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Clinic Patients, City Residents

You may qualify if:

• Age \> 19.
• Patients may or may not be on IOP lowering medication.

You may not qualify if:

• History of baseline corneal disease including but not limited to: Fuchs' Dystrophy, Keratoconus, Iridocorneal Endothelial Syndrome, Lattice Dystrophy, Map-Dot- Fingerprint Dystrophy, or a history of Stevens-Johnson Syndrome.
• Wears hard or rigid contact lenses.
• History of inflammatory eye disease.
• History of ocular trauma within the past 6 months.
• History of ocular infection within the last 3 months.
• Any abnormality preventing reliable IOP readings.
• Subject has demonstrated potential for non-compliance with the study protocol (e.g. dosing schedule, visit schedule, or study procedures).
• History of severe hypersensitivity to topical fluorescein.
• Pregnant or breast feeding women.

Sponsors & Collaborators

• University of Nebraska: lead

Study Sites (2)

University of Nebraska Medical Center, Department of Ophthalmolgy and Visual Sciences

Omaha, Nebraska, 68198-5540, United States

Location

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

Location

MeSH Terms

Conditions

Corneal Diseases

Condition Hierarchy (Ancestors)

Eye Diseases

Study Officials

• Carol B Toris, PhD

  University of Nebraska

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 7, 2007
• First Posted: December 11, 2007
• Study Start: June 29, 2005
• Primary Completion: November 1, 2011
• Study Completion: November 1, 2011
• Last Updated: September 23, 2024

Record last verified: 2024-09

Locations

US (2)