Systemic Glutathione Level in Normal Tension Glaucoma

NCT00570362 | Completed Results

• 2 other identifiers: Merck-001CMCEYE-GSH
• Study Type: observational
• Target: 49
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate whether systemic glutathione level is decreased in patients with normal tension glaucoma.

Conditions

Normal Tension Glaucoma

Keywords

Normal tension glaucoma; Glutathione; Antioxidant

Outcome Measures

Primary Outcomes (1)

• Total Glutathione Levels

  Subjects were instructed to fast from midnight to 8 AM on the morning of the test. All blood samples were obtained by a qualified registered nurse in the morning, between 8 and 10 AM.

  Once in the morning.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients of tertiary referred center

You may qualify if:

• Clinical Diagnosis of Normal Tension Glaucoma: Patients underwent diurnal IOP phasing and were diagnosed as having normal tension glaucoma(IOP always lesser than 22 mm Hg by applanation tonometry), glaucomatous optic disc cupping on fundoscopic examination, open anterior chamber angles by gonioscopy(Schaffer grade III or more), and repeatable VF defects consistent with the diagnosis of glaucoma, according to results obtained with program 24-2 of the Humphrey Field Analyzer.
• Must be able to provide intravenous blood sampling

You may not qualify if:

• Narrow iridocorneal angles
• Any evidence of secondary open-angle glaucoma
• Any other ocular disease except cataract
• History of previous intraocular surgery including cataract
• Any other systemic disease except hypertension
• The control group was composed of age-matched healthy volunteers who had neither glaucoma nor other ocular diseases such as cataract, diabetic retinopathy or age related macular degeneration. The control group did not show any glaucomatous optic disc cupping on fundoscopic examination or visual field defects with program 24-2 of the Humphrey Field Analyzer. The healthy volunteers in the control group must be able to provide intravenous blood sampling.
• Smoking
• History of any chronic systemic disease with presumed low glutathione levels, including autoimmune diseases, alcoholic liver disease, cancer, and diabetes mellitus.

Sponsors & Collaborators

• The Catholic University of Korea: lead

Study Sites (1)

College of Medicine, The Catholic University of Korea, St. Mary's Hospital

Seoul, 150-713, South Korea

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

Low Tension Glaucoma

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases; Optic Nerve Diseases

Results Point of Contact

• Title: Jung-Il Moon
• Organization: St.Mary's Hospital, College of Medicine, The Catholic University of Korea

jimoon@catholic.ac.kr

82-2-3779-2114

Study Officials

• Jung-Il Moon, Professor

  Department of Ophthalmology, St.Mary's Hospital, College of Medicine, The Catholic University of Korea

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 7, 2007
• First Posted: December 10, 2007
• Study Start: March 1, 2008
• Primary Completion: October 1, 2008
• Study Completion: October 1, 2008
• Last Updated: August 10, 2010
• Results First Posted: August 10, 2010

Record last verified: 2007-12

Locations

KR (1)