NCT00569881|CompletedDMC
Effect of Topical Fluoroquinolones on Epithelial Wound Healing After PRK
Effect of Gatifloxacin 0.3% and Moxifloxacin 0.5% on Epithelial Wound Healing After Photorefractive Keratectomy
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Effect of Gatifloxacin 0.3% and Moxifloxacin 0.5% on Epithelial Wound Healing After Photorefractive Keratectomy
Sponsor study identifier
observational
22
0 countries
N/A
Study Start
January 2007
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
March 2007
Actual (reported)The prescribed antibiotic for prophylaxis of infection following PRK should be effective at eradicating a potential infection. In addition, the antibiotic should have a rapid onset of action, effectively penetrate the target tissue, and be safe and not toxic to any layer of the healing cornea, especially the epithelium. Several studies have investigated the toxicity of the fourth generation fluoroquinolones on the corneal epithelium and studies have demonstrated that gatifloxacin is less deleterious to the healing cornea than moxifloxacin. Most of these studies, however, have been conducted in animals. This was a retrospective chart review.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2007
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2007
Date type not reportedThis date has not been verified as actual or estimated.
March 2007
Actual (reported)December 6, 2007
Actual (reported)December 10, 2007
Actual (reported)Wound Healing
Days after PRK
Corneal epithelial wound healing with moxifloxacin
Corneal epithelial wound healing with gatifloxacin
Comparison of wound healing between drugs
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
These entries preserve how the registry describes the intervention. Their treatment roles are shown separately from molecular identities.
Grouped treatment entry
gatifloxacin and moxifloxacin
The registry names several treatments. This does not confirm that participants received them together or that they form a single product.
View registry recordPatients presented to the practice of a cornea trained ophthalmic consultant.
Eric Donnenfeld, MD
OCLI
22 participants (actual enrollment reported by the registry).
First Submitted
December 6, 2007
First Posted
December 10, 2007
Study Start
January 2007
Date type not reportedThis date has not been verified as actual or estimated.
Evaluation of Dexpanthenol and Hyaluronic Acid Eye Drops on Corneal Epithelialization After Trans Epithelial PRK
Contact the study team to confirm eligibility.
Study Completion
March 2007
Actual (reported)Last Updated
December 10, 2007
Record last verified: 2007-12
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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