Agreement Between Venous and Arterial Blood Gas Measurements in the Intensive Care Unit

NCT00569634 | Completed DMC

• 1 other identifier: 07H-821001
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to examine the agreement between venous blood gas and arterial blood gas measurements in patients in the Intensive Care Unit.

Conditions

Acid-Base Balance

Keywords

Venous blood gas; Arterial blood gas; pH; pCO2; Bicarbonate

Outcome Measures

Primary Outcomes (1)

• Agreement between venous and arterial blood gas measurements of pH, pCO2 and bicarbonate

  Duration of Intensive Care Unit Admission

Study Arms (1)

1

OTHER

Procedure: Venous blood gas analysis

Interventions

Venous blood gas analysis PROCEDURE

When an ABG is deemed to be necessary as part of ICU management, a central venous sample will also be obtained with minimum delay (always \< 2 minutes) between the samples. The samples will be analyzed by a blood gas analyzer as quickly as possible.

1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patients 18 years or older
• Admitted to the Intensive Care Unit (ICU)
• Determined by their treating clinicians to require both a central venous line and arterial line

You may not qualify if:

• None

Sponsors & Collaborators

• Olive View-UCLA Education & Research Institute: lead

Related Publications (14)

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  PMID: 6026202 BACKGROUND

• Criscuolo C, Nepper G, Buchalter S. Reflex sympathetic dystrophy following arterial blood gas sampling in the intensive care setting. Chest. 1995 Aug;108(2):578-80. doi: 10.1378/chest.108.2.578.

  PMID: 7634906 BACKGROUND

• Malinoski DJ, Todd SR, Slone S, Mullins RJ, Schreiber MA. Correlation of central venous and arterial blood gas measurements in mechanically ventilated trauma patients. Arch Surg. 2005 Nov;140(11):1122-5. doi: 10.1001/archsurg.140.11.1122.

  PMID: 16342377 BACKGROUND

• Kelly AM, Kyle E, McAlpine R. Venous pCO(2) and pH can be used to screen for significant hypercarbia in emergency patients with acute respiratory disease. J Emerg Med. 2002 Jan;22(1):15-9. doi: 10.1016/s0736-4679(01)00431-0.

  PMID: 11809551 BACKGROUND

• Rang LC, Murray HE, Wells GA, Macgougan CK. Can peripheral venous blood gases replace arterial blood gases in emergency department patients? CJEM. 2002 Jan;4(1):7-15. doi: 10.1017/s1481803500006011.

  PMID: 17637143 BACKGROUND

• Kelly AM, McAlpine R, Kyle E. Agreement between bicarbonate measured on arterial and venous blood gases. Emerg Med Australas. 2004 Oct-Dec;16(5-6):407-9. doi: 10.1111/j.1742-6723.2004.00642.x.

  PMID: 15537402 BACKGROUND

• Kelly AM, McAlpine R, Kyle E. Venous pH can safely replace arterial pH in the initial evaluation of patients in the emergency department. Emerg Med J. 2001 Sep;18(5):340-2. doi: 10.1136/emj.18.5.340.

  PMID: 11559602 BACKGROUND

• Ma OJ, Rush MD, Godfrey MM, Gaddis G. Arterial blood gas results rarely influence emergency physician management of patients with suspected diabetic ketoacidosis. Acad Emerg Med. 2003 Aug;10(8):836-41. doi: 10.1111/j.1553-2712.2003.tb00625.x.

  PMID: 12896883 BACKGROUND

• Gokel Y, Paydas S, Koseoglu Z, Alparslan N, Seydaoglu G. Comparison of blood gas and acid-base measurements in arterial and venous blood samples in patients with uremic acidosis and diabetic ketoacidosis in the emergency room. Am J Nephrol. 2000 Jul-Aug;20(4):319-23. doi: 10.1159/000013607.

  PMID: 10970986 BACKGROUND

• Middleton P, Kelly AM, Brown J, Robertson M. Agreement between arterial and central venous values for pH, bicarbonate, base excess, and lactate. Emerg Med J. 2006 Aug;23(8):622-4. doi: 10.1136/emj.2006.035915.

  PMID: 16858095 BACKGROUND

• Chu YC, Chen CZ, Lee CH, Chen CW, Chang HY, Hsiue TR. Prediction of arterial blood gas values from venous blood gas values in patients with acute respiratory failure receiving mechanical ventilation. J Formos Med Assoc. 2003 Aug;102(8):539-43.

  PMID: 14569318 BACKGROUND

• Brandenburg MA, Dire DJ. Comparison of arterial and venous blood gas values in the initial emergency department evaluation of patients with diabetic ketoacidosis. Ann Emerg Med. 1998 Apr;31(4):459-65. doi: 10.1016/s0196-0644(98)70254-9.

  PMID: 9546014 BACKGROUND

• Ak A, Ogun CO, Bayir A, Kayis SA, Koylu R. Prediction of arterial blood gas values from venous blood gas values in patients with acute exacerbation of chronic obstructive pulmonary disease. Tohoku J Exp Med. 2006 Dec;210(4):285-90. doi: 10.1620/tjem.210.285.

  PMID: 17146193 BACKGROUND

• Malatesha G, Singh NK, Bharija A, Rehani B, Goel A. Comparison of arterial and venous pH, bicarbonate, PCO2 and PO2 in initial emergency department assessment. Emerg Med J. 2007 Aug;24(8):569-71. doi: 10.1136/emj.2007.046979.

  PMID: 17652681 BACKGROUND

Study Officials

• Richard M Treger, M.D.

  Olive View-UCLA Education & Research Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 6, 2007
• First Posted: December 7, 2007
• Study Start: January 1, 2008
• Primary Completion: July 1, 2008
• Study Completion: July 1, 2008
• Last Updated: March 15, 2021

Record last verified: 2021-03