PET-Study: Effects of Single Doses of Stalevo and Levodopa/Carbidopa on Striatal 11C-Raclopride Binding

NCT00562198 | Terminated Phase 2

• 1 other identifier: 2939121
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 5

Brief Summary

This is an open, randomised, active-controlled, 2-period crossover study comparing the effect of single doses of Stalevo 200 and Sinemet on striatal (putamenal and caudate) 11C-raclopride BP in PD patients with wearing-off symptoms. The study consists of 4 visits: a screening visit (visit 1), 2 treatment periods (period 1=visit 2, period 2=visit 3) separated by a minimum wash-out period of at least 3 days, and an end-of-study visit (visit 4). Subjects will be randomly allocated to start the period 1 with a single dose of Stalevo 200 or Sinemet. After the wash-out the study drug on period 2 will be administered according to a crossover design.

Conditions

Parkinson´s Disease

Outcome Measures

Primary Outcomes (1)

• The difference between the study drugs in change in striatal 11C-raclopride BP.Striatal 11C-raclopride BP will be determined with PET scans performed at baseline and from 2.5 to 3.5 h after the study drug administration.

  Post-dosing PET scan

Secondary Outcomes (1)

• The difference between the study drugs in levodopa mean C2.5- 3.5h.

  C 2.5-3.5h

Study Arms (1)

1

EXPERIMENTAL

Investigational drug Stalevo 200

Drug: entacapone and carbidopa; Drug: Sinemet 200mg/50mg

Interventions

entacapone and carbidopa DRUG

Entacapone 200mg carbidopa 50mg

1

Sinemet 200mg/50mg DRUG

Sinemet 200mg/50mg once

1

Eligibility Criteria

• Age: 45 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or female patients with idiopathic Parkinson's disease according to the UK Brain Bank criteria.
• Predictable wearing-off symptoms with a response to standard release levodopa/carbidopa (200/50 mg)during the levodopa challenge test lasting for a minimum of 1.5 h and a maximum of 4 h.
• The magnitude of response (peak effect) in the levodopa challenge test is at least 30%. The magnitude of response is defined to be the difference between the baseline score and the lowest UPDRS III score during the levodopa challenge test.
• Hoehn and Yahr stage of at least 2.0 performed during the "ON" state.
• Treatment with at least 4 daily doses of levodopa/dopa decarboxylase inhibitor (DDCI) (± entacapone(Comtess® or Stalevo) with total daily levodopa dose in the range of 400-1200mg.
• Unchanged levodopa/DDCI ± entacapone and other antiparkinsonian medication \[dopamine agonists,monoamine oxidase B (MAO-B) inhibitor, amantadine and/or anticholinergics with an approved dose\], if any, for at least 2 weeks prior to period I.
• Written informed consent obtained.
• Age of 45-80 years, inclusive.

You may not qualify if:

• Secondary or atypical parkinsonism.
• Patients with any unpredictable "OFF"-periods.
• Patients with moderate to severe treatment-related peak-dose dyskinesia likely to affect the quality of brain magnetic resonance image (MRI) or positron emission tomography (PET) imaging.
• Failure to adequately respond to the levodopa (levodopa/carbidopa 200/50 mg) challenge test with the duration of response lasting less than 1.5 h or more than 4 h.
• Presence of a basal ganglia lesion in the MRI image or any other factor(s) that would make MRI or PET imaging likely to be unsatisfactory.
• Presence of any ferromagnetic objects that would make brain MRI imaging contraindicated.
• Patients with a history of laboratory abnormality consistent with, or clinically significant cardiovascular,pulmonary, gastrointestinal, hepatic, renal, neurological or psychiatric disorder or any other major concurrent illness, which may influence the outcome of the study including the interpretation and usage of MRI and PET images for the study purposes.
• History of neuroleptic malignant syndrome (NMS) and/or non-traumatic rhabdomyolysis, malignant melanoma, narrow-angle glaucoma or pheochromocytoma.
• Severe hepatic impairment.
• Any abnormal electrocardiogram (ECG) finding with clinical relevance.
• Female patients of childbearing potential (menstruating or less than 2 years post-menopausal) if they are not using adequate contraception during the study (defined as hormonal contraception, intrauterine device or surgical sterilization) or female patients who are pregnant or lactating.
• Treatment with cabergoline.
• Concomitant treatment with apomorphine, MAO-A inhibitors or non-selective MAO inhibitors.
• Concomitant treatment with any drugs with antidopaminergic action (e.g. with D2 receptor blocking properties) less than two weeks or within five times the elimination half-life of a given drug prior to the first study drug administration. As an exception, the use of domperidone is allowed.
• Current, regular use of any iron preparation that cannot be interrupted for the duration of the study

Sponsors & Collaborators

• Orion Corporation, Orion Pharma: lead

Study Sites (5)

Helsinki University Hospital, Department of Neurology

Helsinki, 00029, Finland

Location

Oulu University Hospital, Department of Neurology

Oulu, 90220, Finland

Location

Porin Lääkäritalo

Pori, 28100, Finland

Location

FinnMedi Tutkimus Oy

Tampere, 33520, Finland

Location

CRST

Turku, 20520, Finland

Location

MeSH Terms

Conditions

Parkinson Disease

Interventions

entacapone; Carbidopa; carbidopa, levodopa drug combination

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Methyldopa; Dihydroxyphenylalanine; Catecholamines; Amines; Organic Chemicals; Hydrazines; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons

Study Officials

• Juha Rinne, Dr

  Turku PET Centre, Turku, Finland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY

Study Record Dates

• First Submitted: November 19, 2007
• First Posted: November 21, 2007
• Study Start: January 1, 2008
• Primary Completion: February 1, 2008
• Study Completion: May 1, 2008
• Last Updated: June 16, 2008

Record last verified: 2008-06

Locations

FI (5)