NCT00557765

Brief Summary

After exposure to an active case of tuberculosis (TB), close contacts may be infected. They are then considered as having latent tuberculosis infection (LTBI). Detecting LTBI is the main goal of contact tracing procedures after exposure to TB. Until recently, the only test available for detecting LTBI was the tuberculin skin test (TST). More recent tests are now available (Interferon-gamma release assays: IGRA), which are more specific and sensitive than the TST. This study compares the TST and an IGRA in the routine activity of contact tracing in our area.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
295

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2004

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2004

Completed
1.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2006

Completed
1.9 years until next milestone

First Submitted

Initial submission to the registry

November 13, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 14, 2007

Completed
Last Updated

November 14, 2007

Status Verified

November 1, 2007

First QC Date

November 13, 2007

Last Update Submit

November 13, 2007

Conditions

TuberculosisLatent Tuberculosis Infection

Keywords

TuberculosisLatent tuberculosis infectionInterferon gamma release assayContact tracing

Outcome Measures

Primary Outcomes (1)

  • Correlation between results of TST and IGRA tests and exposure scores

    2 months after exposure

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All subjects screened after exposure to a case of active and contagious tuberculosis in the Geneva area

You may qualify if:

  • Exposure to a case of contagious TB
  • Willingness to participate in study

You may not qualify if:

  • Known HIV infection
  • Known previous TB or treatment for LTBI

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre antituberculeux; Geneva University Hospital

Geneva, Canton of Geneva, 1211, Switzerland

Location

MeSH Terms

Conditions

TuberculosisLatent Tuberculosis

Condition Hierarchy (Ancestors)

Mycobacterium InfectionsActinomycetales InfectionsGram-Positive Bacterial InfectionsBacterial InfectionsBacterial Infections and MycosesInfectionsLatent Infection

Study Officials

  • Jean-Paul Janssens, M.D.

    Centre antituberculeux

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

November 13, 2007

First Posted

November 14, 2007

Study Start

October 1, 2004

Study Completion

January 1, 2006

Last Updated

November 14, 2007

Record last verified: 2007-11

Locations

CH(1)