PERG and mfPERG in Band Atrophy

NCT00553761 | Completed

• 2 other identifiers: 654/06FAPESP 06/61549-6; 07/54142-0)
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The study is designed to evaluate the ability of pattern electroretinogram (PERG) and multifocal pattern electroretinogram (mfPERG) to measure and identify the pattern of band atrophy of the optic nerve in patients with long standing chiasmal lesions. The hypothesis is that these electrophysiological tests were able to identify this such pattern. The idea is to investigate the ability of the these electrophysiological technics in detecting the neural loss from chiasmal compression and to evaluate the ability of PERG and mfPERG parameters to differentiate between eyes with band atrophy of the optic nerve and healthy eyes.

Conditions

Band Atrophy

Keywords

Band atrophy; Pattern electroretinogram; Chiasmal compression; Neural loss; Electrophysiological tests

Interventions

Pattern electroretinogram DEVICE

Full field and hemifield (nasal and temporal) stimulation transient pattern electroretinogram (PERG) were recorded both in patients and controls.

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with band atrophy from chismal compression and controls

You may qualify if:

• Visual acuity better than 20/30
• Refractive error less 5 spherical diopter and 3 cylinder diopter
• Temporal field defect

You may not qualify if:

• Presence of glaucoma and optic nerve anomalies
• Anormal nasal field

Sponsors & Collaborators

• University of Sao Paulo: lead
• Fundação de Amparo à Pesquisa do Estado de São Paulo: collaborator

Study Sites (1)

Universidade de São Paulo

São Paulo, São Paulo, 05403-000, Brazil

Location

Related Publications (4)

• Monteiro ML, Hokazono K, Cunha LP, Oyamada MK. Correlation between multifocal pattern electroretinography and Fourier-domain OCT in eyes with temporal hemianopia from chiasmal compression. Graefes Arch Clin Exp Ophthalmol. 2013 Mar;251(3):903-15. doi: 10.1007/s00417-012-2156-8. Epub 2012 Sep 29.

  PMID: 23052713 DERIVED

• Monteiro ML, Hokazono K, Cunha LP, Oyamada MK. Multifocal pattern electroretinography for the detection of neural loss in eyes with permanent temporal hemianopia or quadrantanopia from chiasmal compression. Br J Ophthalmol. 2012 Jan;96(1):104-9. doi: 10.1136/bjo.2010.199661. Epub 2011 Mar 17.

  PMID: 21415059 DERIVED

• Monteiro ML, Cunha LP, Costa-Cunha LV, Maia OO Jr, Oyamada MK. Relationship between optical coherence tomography, pattern electroretinogram and automated perimetry in eyes with temporal hemianopia from chiasmal compression. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3535-41. doi: 10.1167/iovs.08-3093. Epub 2009 Mar 5.

  PMID: 19264884 DERIVED

• Cunha LP, Oyamada MK, Monteiro ML. Pattern electroretinograms for the detection of neural loss in patients with permanent temporal visual field defect from chiasmal compression. Doc Ophthalmol. 2008 Nov;117(3):223-32. doi: 10.1007/s10633-008-9126-9. Epub 2008 Apr 10.

  PMID: 18401605 DERIVED

Related Links

• Pattern Electroretinograms For the Detection of Neural Loss in Patients with Permanent Temporal Visual Field Defect from Chiasmal Compression

Study Officials

• Mário Luiz R Monteiro, PhD

  University of Sao Paulo

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: November 5, 2007
• First Posted: November 6, 2007
• Study Start: August 1, 2006
• Primary Completion: July 1, 2008
• Study Completion: July 1, 2009
• Last Updated: August 8, 2011

Record last verified: 2007-11

Locations

BR (1)