NCT00544622

Brief Summary

Background/Aim of the study: To further reduce the 6 months stroke morbidity and mortality in a high volume stroke hospital and to compare the results with national and international data. Methods: 204 consecutive stroke patients are analyzed in a prospective study in a single center teaching institution. The intervention consists of a structured therapeutic chain of 290 collaborating GPs, a standardised acute hospital proceeding overlapping with an early integrated neurovascular rehabilitation within the same institution. Primary endpoints include death and dependence at 6 months, secondary endpoints are the length of hospital stay (LOS) and the quantitative analysis of physical and psychosocial impairments. The data are directly compared with the same endpoints of the Swiss subgroup of the international stroke trial (IST).

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jan 2002

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2002

Completed
1.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2003

Completed
4.6 years until next milestone

First Submitted

Initial submission to the registry

October 12, 2007

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 16, 2007

Completed
Last Updated

October 17, 2008

Status Verified

October 1, 2008

First QC Date

October 12, 2007

Last Update Submit

October 16, 2008

Conditions

Keywords

Stroke treatmentRehabilitationStroke chainStroke unit

Outcome Measures

Primary Outcomes (2)

  • Mortality, dependence, psychoscial outcome

  • Mortality, dependence and psychosocial outcome

    6 months endpoint

Interventions

Eligibility Criteria

Age20 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • An acute cerebrovascular event (ischemic stroke or intra-cerebral bleeding (ICB)) with the signs and symptoms of an acute stroke according to the World Health Organisation definition of acute stroke14 within the last 12 hours without the need or possibility of a neurosurgical intervention
  • No thrombolytic therapy within the first 3 hours (in order to allow the correct comparison with the Swiss cohort of the IST trial
  • The informed consent of the patient or, if not possible, of the relatives
  • Living at home before the event
  • Lack of participation in another trial.

You may not qualify if:

  • Thrombolytic therapy within the first 3 hours (in order to allow the correct comparison with the Swiss cohort of the IST trial
  • No informed consent of the patient or, if not possible, of the relatives
  • Not living at home before the event
  • Participation in another trial (26 patients were excluded because of TIA with full recovery within 24 hours after the event)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Langhorne P, Ramachandra S; Stroke Unit Trialists' Collaboration. Organised inpatient (stroke unit) care for stroke: network meta-analysis. Cochrane Database Syst Rev. 2020 Apr 23;4(4):CD000197. doi: 10.1002/14651858.CD000197.pub4.

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Juerg H. Beer, MD

    Department of Medicine

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER

Study Record Dates

First Submitted

October 12, 2007

First Posted

October 16, 2007

Study Start

January 1, 2002

Study Completion

March 1, 2003

Last Updated

October 17, 2008

Record last verified: 2008-10