NCT00540670

Brief Summary

The purpose of this study is to assess the safety and tolerability of E5555 in Japanese subjects with coronary artery disease.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
240

participants targeted

Target at P75+ for phase_2 coronary-artery-disease

Geographic Reach
1 country

25 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2007

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

October 4, 2007

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 8, 2007

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2009

Completed
Last Updated

May 13, 2013

Status Verified

February 1, 2010

Enrollment Period

1.4 years

First QC Date

October 4, 2007

Last Update Submit

May 9, 2013

Conditions

Keywords

Coronary artery disease

Outcome Measures

Primary Outcomes (1)

  • Safety and tolerability: Adverse events, bleeding events, clinical laboratory tests, Coagulation tests, vital signs and 12-lead ECG

    6 months

Secondary Outcomes (1)

  • Major cardiac adverse events, biomarkers, platelet aggregation inhibition, plasma concentration.

    6 months

Study Arms (4)

1

EXPERIMENTAL
Drug: E5555 50 mg

2

EXPERIMENTAL
Drug: E5555 100 mg

3

EXPERIMENTAL
Drug: E5555 200 mg

4

PLACEBO COMPARATOR
Drug: Placebo

Interventions

E5555 50 mg (tablet) taken orally, once a day.

1

E5555 100 mg (tablet) taken orally, once a day.

2

E5555 200 mg (tablet) taken orally, once a day.

3

Placebo (tablet) taken orally, once a day.

4

Eligibility Criteria

Age45 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years old (at time of informed consent).
  • Male or female (females of childbearing potential must use contraception).
  • Confirmed coronary artery disease.
  • All subjects must be receiving aspirin (75 - 325 mg).

You may not qualify if:

  • Unwilling or unable to provide informed consent.
  • History of acquired or congenital bleeding disorder, coagulopathy, or platelet disorder.
  • Recent trauma or major surgery.
  • Evidence of active pathological bleeding or history of bleeding such as gastrointestinal or genitourinary, unless the cause has been definitely corrected.
  • History of intracranial bleeding or history of hemorrhagic retinopathy.
  • New York Heart Association class III or IV congestive heart failure.
  • Pregnant or lactating women.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (25)

Unknown Facility

Ichinomiya, Aichi-ken, Japan

Location

Unknown Facility

Gifu, Gifu, Japan

Location

Unknown Facility

Ōgaki, Gifu, Japan

Location

Unknown Facility

Asahikawa, Hokkaido, Japan

Location

Unknown Facility

Chitose, Hokkaido, Japan

Location

Unknown Facility

Sapporo, Hokkaido, Japan

Location

Unknown Facility

Tomakomai, Hokkaido, Japan

Location

Unknown Facility

Himeji, Hyōgo, Japan

Location

Unknown Facility

Nishinomiya, Hyōgo, Japan

Location

Unknown Facility

Tsuchiura, Ibaraki, Japan

Location

Unknown Facility

Kanazawa, Ishikawa-ken, Japan

Location

Unknown Facility

Yokohama, Kanagawa, Japan

Location

Unknown Facility

Kumamoto, Kumamoto, Japan

Location

Unknown Facility

Matsusaka, Mie-ken, Japan

Location

Unknown Facility

Tsu, Mie-ken, Japan

Location

Unknown Facility

Osaka, Osaka, Japan

Location

Unknown Facility

Sayama, Osaka, Japan

Location

Unknown Facility

Kitamoto, Saitama, Japan

Location

Unknown Facility

Saitama, Saitama, Japan

Location

Unknown Facility

Shizuoka, Shizuoka, Japan

Location

Unknown Facility

Bunkyo-ku, Tokyo, Japan

Location

Unknown Facility

Musashino, Tokyo, Japan

Location

Unknown Facility

Ōta-ku, Tokyo, Japan

Location

Unknown Facility

Shinjuku-ku, Tokyo, Japan

Location

Unknown Facility

Tachikawa, Tokyo, Japan

Location

MeSH Terms

Conditions

Coronary Artery Disease

Interventions

E 5555

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Study Officials

  • Masaru Takeuchi

    New Product Development, Clinical Research Center, Eisai Co., Ltd.

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 4, 2007

First Posted

October 8, 2007

Study Start

October 1, 2007

Primary Completion

March 1, 2009

Last Updated

May 13, 2013

Record last verified: 2010-02

Locations