GSK706769 A First Time in Human Study For Males and Females

NCT00539201 | Terminated Phase 1

• 1 other identifier: CRR110198
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

To determine safety, tolerability and pharmacokinetics of GSK706769

Conditions

Healthy Subjects

Keywords

GSK706769,; CCR5 inhibitor,; HIV

Outcome Measures

Primary Outcomes (3)

• Blood levels of drug

  over 48 hours or 14 days.

• Laboratory test results

  over 48 hours or 14 days

• Vital signs

  over 48 hours or 14 days

Secondary Outcomes (12)

• Effect of food on blood levels of drug

  over 48 hours

• Effect of Kaletra on blood levels of drug

  over 48 hours

• Effect of midazolam on drug levels

  over 12 hours

• Plasma GSK706769 PK parameters, AUC(0-∞) or AUC(0-t), Cmax, tmax and tlag following single dose administration of a given dose of GSK706769 with and without high fat/calorie meal.

• Plasma GSK706769 PK parameters, AUC(0-∞), AUC(0-t), Cmax, C12, and t1/2 following a single dose of GSK706769 with and without a single dose of LPV/RTV 400/100mg.

Interventions

GSK706769 DRUG

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• The subject is healthy. Healthy, as judged by a responsible physician, with no clinically significant abnormality identified on the medical or laboratory evaluation, including 12-lead ECG. A subject with a clinical abnormality or laboratory parameters outside the reference range for this age group may be included only if the Investigator considers that the finding will not introduce additional risk factors and will not interfere with the study procedures.
• The subject is ≥18 and ≤65 years of age.
• The subject is male or female.
• A female is eligible to enter and participate in this study if she is of non-childbearing potential (i.e., physiologically incapable of becoming pregnant), including any female who:
• Has had a hysterectomy or
• Has had a bilateral oophorectomy (removal of the ovaries) or
• Has had a bilateral tubal ligation or
• Is post-menopausal (a demonstration of total cessation of menses for ≥ 1 year from the date of screening visit). An FSH level will be performed to confirm a post-menopausal state. For this study FSH levels ≥ 40mIU/mL are consistent with menopause. If a subject is on estrogen replacement and menopausal status is questionable, estrogen replacement should be discontinued for 2 weeks and then the subject rescreened, as estrogen replacement can suppress FSH.
• A male is eligible to enter and participate in the study if he is surgically sterile OR if he either agrees to abstain from sexual intercourse with a female partner or agrees to use a condom/spermicide, in addition to having his female partner use another form of contraception, such as an IUD, occlusive cap (diaphragm or cervical/vault cap) with spermicide, oral contraceptives, injectable progesterone, subdermal implants, female condom, contraceptive patch, or contraceptive vaginal ring, or has had a tubal ligation or hysterectomy. These criteria must be followed from the time of the first dose of study medication until 84 days after the last dose of study medication.
• Body weight ≥ 50 kg (110 lbs.) for men and ≥ 45 kg (99 lbs.) for women and body mass index (BMI) between 18.5-29.9 kg/m2 inclusive.
• A signed and dated written informed consent is obtained from the subject prior to screening.
• The subject is able to understand and comply with protocol requirements, instructions and protocol-stated restrictions and is likely to complete the study as planned.

You may not qualify if:

• As a result of the medical interview, physical examination, or screening investigations, the Investigator considers the subject unfit for the study.
• The subject's systolic blood pressure is outside the range of 90-140mmHg, or diastolic blood pressure is outside the range of 45-90mmHg or heart rate is outside the range of 50-100bpm for female subjects or 45-100bpm for male subjects.
• History/evidence of symptomatic or asymptomatic arrhythmia, angina/ischemia, coronary artery bypass grafting surgery or percutaneous transluminal coronary angioplasty or any clinically significant cardiac disease.
• History/evidence of clinically significant pulmonary disease.
• Has a positive pre-study Hepatitis B surface antigen; positive HCV antibody; or positive HIV-1 antibody result.
• Has a history of regular alcohol consumption averaging \>7 drinks/week for women or \>14 drinks/week for men (1 drink (12 g alcohol) = 5 ounces (150 ml) of wine or 12 ounces (360 ml) of beer or 1.5 ounces (45 ml) of 80 proof distilled spirits) within 6 months of the screening visit.
• Unwilling to abstain from alcohol for 72 hours prior to the start of dosing until collection of the final pharmacokinetic sample during each treatment period.
• Has a history of regular use of tobacco- or nicotine-containing products within 3 months of the screening visit.
• The subject has a positive pre-study drug and/or alcohol screen.
• Unwilling to refrain from the use of illicit drugs and adhere to other protocol-stated restrictions while participating in the study.
• The subject has received an investigational drug or participated in any other research trial within 30 days or 5 half-lives, or twice the duration of the biological effect of any drug (whichever is longer) prior to the first dose of current study medication.
• Participation in the study would result in donation of blood in excess of 500 mL within a 56 day period.
• History or presence of allergy or intolerance to the study drugs or their components or drugs of their class, or a history of drug or other allergy that, in the opinion of the physician responsible, contraindicates their participation. This includes subjects with a history of known or suspected sulfa related hypersensitivity. In addition, if heparin is used during PK sampling, subjects with a history of sensitivity to heparin or heparin-induced thrombocytopenia should not be enrolled. Note: "Study" or "investigational" drugs includes GSK706769, placebo, lopinavir, ritonavir, midazolam, and flumazenil.
• Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study medication, unless in the opinion of the Investigator and sponsor the medication will not interfere with the study procedures or compromise subject safety.
• Aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, or serum creatinine values greater than the upper limit of normal or hemoglobin outside the normal range at screening. A single repeat is allowed for eligibility determination.

Sponsors & Collaborators

• GlaxoSmithKline: lead

Study Sites (1)

GSK Investigational Site

Madison, Wisconsin, 53704, United States

Location

Study Officials

• GSK Clinical Trials, MD

  GlaxoSmithKline

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY

Study Record Dates

• First Submitted: October 2, 2007
• First Posted: October 4, 2007
• Study Start: September 1, 2007
• Primary Completion: February 1, 2008
• Study Completion: February 1, 2008
• Last Updated: October 19, 2010

Record last verified: 2010-10

Locations

US (1)