NCT00538707

Brief Summary

The aim of the project is to study the acute and chronic effect of mental stress on platelet adhesion and aggregation in two population composed of normal subjects at different ages

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
32

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Sep 2007

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2007

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

October 2, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 3, 2007

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2009

Completed
Last Updated

February 10, 2010

Status Verified

February 1, 2010

Enrollment Period

2.3 years

First QC Date

October 2, 2007

Last Update Submit

February 9, 2010

Conditions

Mental Stress

Keywords

mental stressplatelet adhesionplatelet functioncatecholamines

Outcome Measures

Primary Outcomes (1)

  • Evaluation of platelet function (shear stress dependent platelet adhesion and aggregation) before and after mental stress

    60 minutes

Secondary Outcomes (1)

  • Evaluation of the plasma level of endothelin, catecholamines and salivary cortisol level before and after mental stress

    60 minutes

Study Arms (2)

Young subjects

EXPERIMENTAL
Behavioral: 2-minute Bondet test

Older subjects

EXPERIMENTAL
Behavioral: 2-minute Bondet test

Interventions

2-minute Bondet testBEHAVIORAL

2-minute Bondet test

Also known as: 2-minute Bondet light test
Older subjectsYoung subjects

Eligibility Criteria

Age20 Years - 70 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • healthy subjects between 20 - 70 years of age
  • written informed consent
  • no evidence of diseases

You may not qualify if:

  • pregnancy
  • oral contraceptives
  • smoking
  • use of aspirin or NSAIDs within the last week
  • use of benzodiazepines within the last week
  • Alcohol or drug abuse
  • participation in another study within the last month

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital of Zurich

Zurich, Switzerland

Location

MeSH Terms

Conditions

Stress, Psychological

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehavior

Study Officials

  • Georg Noll, MD

    University of Zurich

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

October 2, 2007

First Posted

October 3, 2007

Study Start

September 1, 2007

Primary Completion

December 1, 2009

Study Completion

December 1, 2009

Last Updated

February 10, 2010

Record last verified: 2010-02

Locations

CH(1)