NCT00537004

Brief Summary

The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
500

participants targeted

Target at P75+ for all trials

Timeline
11mo left

Started May 2007

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress95%
May 2007Apr 2027

Study Start

First participant enrolled

May 1, 2007

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

September 26, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 28, 2007

Completed
19.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2027

Last Updated

February 27, 2026

Status Verified

February 1, 2026

Enrollment Period

19.9 years

First QC Date

September 26, 2007

Last Update Submit

February 24, 2026

Conditions

Primary Progressive Aphasia

Keywords

primary progressive aphasiafrontotemporal dementiasemantic dementiaprogressive nonfluent aphasiaprogressive aphasiafrontotemporal lobar degeneration

Outcome Measures

Primary Outcomes (1)

  • Neuropsychological variables

    Immediately after testing and at two years post-testing

Study Arms (2)

PPA (Primary Progressive Aphasia)

Individuals with primary progressive aphasia

Control

Individuals with no diagnosis of any type of dementia

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participants with PPA will be recruited from the Northwestern University Alzheimer's Disease Center Core registry, the Northwestern University Neurobehavior and Memory Clinic, and from those who contact the center that are interested in PPA research.

You may qualify if:

  • Diagnosis of primary progressive aphasia
  • Right-handed
  • Native English speaker
  • Visual acuity of 20/30 corrected
  • Adequate hearing to follow conversation
  • Safe for an MRI scan

You may not qualify if:

  • Left-handedness
  • Claustrophobia
  • Presence of significant medical illness that initially or in the future could interfere with continued participation in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Northwestern University

Chicago, Illinois, 60611, United States

RECRUITING

Related Publications (3)

  • Mesulam MM. Slowly progressive aphasia without generalized dementia. Ann Neurol. 1982 Jun;11(6):592-8. doi: 10.1002/ana.410110607.

    PMID: 7114808BACKGROUND

  • Weintraub S, Rubin NP, Mesulam MM. Primary progressive aphasia. Longitudinal course, neuropsychological profile, and language features. Arch Neurol. 1990 Dec;47(12):1329-35. doi: 10.1001/archneur.1990.00530120075013.

    PMID: 2252450BACKGROUND

  • Mesulam MM, Coventry C, Kuang A, Bigio EH, Mao Q, Flanagan ME, Gefen T, Sridhar J, Geula C, Zhang H, Weintraub S, Rogalski EJ. Memory Resilience in Alzheimer Disease With Primary Progressive Aphasia. Neurology. 2021 Feb 9;96(6):e916-e925. doi: 10.1212/WNL.0000000000011397. Epub 2021 Jan 13.

    PMID: 33441454DERIVED

Related Links

MeSH Terms

Conditions

Aphasia, Primary ProgressiveFrontotemporal DementiaPrimary Progressive Nonfluent AphasiaAphasiaFrontotemporal Lobar Degeneration

Condition Hierarchy (Ancestors)

DementiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesSpeech DisordersLanguage DisordersCommunication DisordersNeurobehavioral ManifestationsNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsNeurocognitive DisordersMental DisordersTDP-43 ProteinopathiesNeurodegenerative DiseasesProteostasis DeficienciesMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Marsel Mesulam, MD

    Northwestern University Feinberg School of Medicine

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Elizabeth A Haynes

CONTACT

312-503-2398PPA.Research@northwestern.edu

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director, Mesulam Center for Cognitive Neurology and Alzheimer's Disease

Study Record Dates

First Submitted

September 26, 2007

First Posted

September 28, 2007

Study Start

May 1, 2007

Primary Completion (Estimated)

April 1, 2027

Study Completion (Estimated)

April 1, 2027

Last Updated

February 27, 2026

Record last verified: 2026-02

Locations

US(1)