A Phase IIa Study of Subcutaneous AER 001 on Antigen Challenge In Atopic Asthmatic Subjects (28 Day Study)

NCT00535028 | Completed Phase 2

• 2 other identifiers: QGUY/2004/IL4-13/-01EUDRACT 2004-002836-25
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This is a single center, double-blind, randomised parallel group design study to investigate the effects of AER 001 on the late phase asthmatic resonse in asthmatic subjects. AER 001 is to be administered subcutaneously (25 mg, once daily) for 28 days. The asthmatic subjects will be challenged with allergen both before and after AER 001 treatment (at screen and at Day 28). The primary outcome will be late phase sthmatic response (the max drop in FEV1 from 4-10 hours after an allergen challenge).

Conditions

Allergic Asthma

Keywords

asthma; allergy; interleukin-4; interleukin-13; IL-4; IL-13; atopic; late asthmatic response; inflammation

Outcome Measures

Primary Outcomes (1)

• Max %fall in FEV1 during the late phase asthmatic response (4-10 hours after allergen challenge)

  After 28 days of treatment with study medication

Secondary Outcomes (1)

• To examine the effects of AER 001 on cutaneous antigen response, antigen induced airway hyperactivity and sputum eosinophilia.

  After 28 days of treatment with study medication

Study Arms (2)

A

EXPERIMENTAL

AER 001 s.c. once daily for 28 days

Drug: AER 001

P

PLACEBO COMPARATOR

placebo s.c. once daily for 28 days

Drug: placebo

Interventions

AER 001 DRUG

AER 001 25 mgs s.c. once daily for 28 days

A

placebo DRUG

sterile saline

P

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult males and females \> 18 years.
• Subjects who if female, are not currently pregnant or breast feeding and are using medically acceptable methods of contraception.
• Subjects who have a pre study medical history, physical examination, 12 Lead ECG acceptable to the investigator.
• Subjects who have clinical laboratory tests within the reference ranges or clinically acceptable to the investigator.
• Subjects who are negative for HbsAg, hepatitis C antibody and HIV II and I test at screening.
• Subjects who are negative for drugs of abuse and alcohol tests at screening and admission.
• Positive response on screening to a skin prick test.
• Subjects who respond \< 8 mg / mL on the methacholine challenge.
• Subjects, who on the Allergen challenge, have a PC20 on allergen and exhibit a late phase response (\>or = 15% between 4-10h) following the allergen challenge.
• Subjects who have a FEV1 \>70% of predicted.
• Have not received steroid treatment in the prior month.
• Subjects who are non-smokers for at least 3 months prior to screening.
• Have a \< 10 pack year history.
• Satisfies the Global Initiative in Asthma (GINA, 2002) definition of asthma or have been on treatment for asthma.
• Subjects with stable, adequately treated medical conditions may be enrolled provided the Principal Investigator does not consider their study participation to place them at increased risk of adverse events. Subjects should continue their concomitant treatments without change during the study.

You may not qualify if:

• Subjects who have a clinically relevant history or presence of respiratory, gastrointestinal, renal, hepatic, haematological, lymphatic, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, dermatological, connective tissue diseases or disorders. Which would preclude antigen challenge
• Subjects who have a clinically relevant surgical history. Which would preclude antigen challenge
• Subjects who have a clinically relevant family history. Which would preclude antigen challenge
• Subjects who have a history of relevant drug hypersensitivity.
• Subjects who have a history of alcoholism.
• Subjects who have a history of drug abuse.
• Subjects who consume more than 28 units of alcohol a week. (unit = 1 glass of wine = 1 measure of spirits = ½ pint of beer)
• Subjects who have a significant infection or known inflammatory process on screening.
• Subjects who have acute gastrointestinal symptoms at the time of screening and/or admission (e.g. nausea, vomiting, diarrhoea, heartburn)
• Subjects who have an acute infection such as influenza at the time of screening and/or admission.
• Female subjects who are not using an acceptable method of contraception.
• Subjects who have used any investigational drug and /or participated in any clinical trial within 3 months of their first dosing.
• Subjects using medication, which in the opinion of the Investigator will affect the outcome of the study.
• Subjects who have donated and/or received any blood or blood products within the previous 3 months prior to first dosing (to review on a case by case basis).
• Subjects who cannot communicate reliably with the investigator.

Sponsors & Collaborators

• Aerovance, Inc.: lead
• Quintiles, Inc.: collaborator

Study Sites (1)

Guy's Drug Research Unit, Quintiles, Ltd.

6 Newcomen Street London, London, SE1 1YR, United Kingdom

Location

Related Publications (1)

• Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet. 2007 Oct 20;370(9596):1422-31. doi: 10.1016/S0140-6736(07)61600-6.

  PMID: 17950857 DERIVED

MeSH Terms

Conditions

Asthma; Hypersensitivity; Rhinitis, Allergic; Inflammation

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Immune System Diseases; Rhinitis; Nose Diseases; Otorhinolaryngologic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Darren Wilbraham, M.D.

  Guy's Drug Research Unit, Quintiles, Ltd.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY

Study Record Dates

• First Submitted: September 21, 2007
• First Posted: September 26, 2007
• Study Start: January 1, 2005
• Study Completion: May 1, 2005
• Last Updated: September 26, 2007

Record last verified: 2007-09

Locations

GB (1)