Study to Determine if Serum BNP Levels Are Elevated in Pregnant Women With Pre-Eclampsia

NCT00533871 | Completed

• 1 other identifier: 2003H0020
• Study Type: observational
• Target: 61
• Locations: 1 country
• Sites: 1

Brief Summary

Preeclampsia is a common disease state occurring in the third trimester of pregnancy, with an incidence of approximately 5-10% in the US. Hypertension (high blood pressure), a primary symptom of pre-eclampsia, may be present in women who were hypertensive prior to becoming pregnant.B-type (also known as brain) natriuretic peptide (BNP) is known to be made and released from the heart ventricles when the heart is strained. There is also evidence that BNP is secreted in the placenta, and may increase in preeclampsia and chronic hypertension in pregnancy.The purpose of the study is to determine if a maternal blood sample analyzed for the quantity of BNP is helpful in differentiating between pre-eclampsia and chronic high blood pressure.

Conditions

Preeclampsia

Keywords

Natriuretic Peptide Brain

Study Arms (3)

Normotensive

Pregnant women in the third trimester with normal blood pressure this pregnancy and no history of HTN or pre-eclampsia in a previous pregnancy

Chronic Hypertensive

Pregnant women in their third trimester with known hypertension prior to the current pregnancy

Pre-eclampsia

Pregnant women in their third trimester who meet ACOG diagnostic criteria for pre-eclampsia

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Pregnant women age 18 or older at 34 or more weeks of pregnancy
• Control arm:normal blood pressure during pregnancy
• Chronic HTN arm: known to have HTN predating this gestation
• Pre-eclampsia arm:meet ACOG diagnostic criteria for pre-eclampsia this pregnancy and present to labor and delivery for evaluation and/ or treatment

You may not qualify if:

• minors, prisoners,unable to provide consent
• multiple gestation
• currently in labor
• Control arm:presence of hypertension, a history of gestational hypertension, current therapy with an anti-hypertensive medication, any history of congestive heart failure
• Chronic HTN arm:evidence of superimposed preeclampsia at the time of enrollment (headache, proteinuria, peripheral edema, or visual changes), any history of congestive heart failure
• Pre-eclampsia arm:history of congestive heart failure, pretreatment with anti-hypertensive medication

Sponsors & Collaborators

• Ohio State University: lead

Study Sites (1)

The Ohio State University

Columbus, Ohio, 43210, United States

Location

MeSH Terms

Conditions

Pre-Eclampsia

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Brian C Hiestand, MD

  Ohio State University Department of Emergency Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 21, 2007
• First Posted: September 24, 2007
• Study Start: February 1, 2003
• Study Completion: June 1, 2005
• Last Updated: September 24, 2007

Record last verified: 2007-09

Locations

US (1)