Pilot Study to Identify the Influence of Genetic Profile Aberrations on Patients With Recurrent Hernias

NCT00527670 | Terminated

• 1 other identifier: MO-1057938
• Study Type: observational
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to compare collagen composition in the skin and fascia of patients with recurrent or incisional hernias versus normal controls. We will identify potential genes responsible for genetic alterations in collagen deposition by using gene chip analysis of the tissue obtained and comparing the hernia group versus controls. The ultimate goal of this study is to identify target genes which may help us eventually predict which patients are at risk for developing post-operative hernias.

Conditions

Pathological Processes

Keywords

Genomics

Study Arms (2)

Normal Controls

Healthy patients undergoing laparoscopic surgery for cholelithiasis, appendicitis, and adrenalectomy.

Procedure: Normal Controls

Recurrent Hernia

Patients presenting for laparoscopic repair of ventral or incisional hernias.

Procedure: Recurrent Hernia

Interventions

Normal Controls PROCEDURE

The control group will have small slivers of tissue removed from the skin and abdomen during surgery to compare genomic information.

Normal Controls

Recurrent Hernia PROCEDURE

This group will have small slivers of tissue removed from the skin and abdomen during hernia repair surgery to find genetic proof of hernias being inherited.

Recurrent Hernia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Surgical patients at the University of Missouri Healthcare system.

You may qualify if:

• Hernia Group: Diagnosis of ventral or incisional hernia.
• Control Group: appendicitis, symptomatic cholelithiasis or cholecystitis, adrenal disease necessitating adrenalectomy.
• Scheduled for an appropriate laparoscopic repair of above diagnosis.
• Females only: Not pregnant.

You may not qualify if:

• Steroid use
• Severe COPD or pulmonary disorders
• History of a connective tissue disorder

Sponsors & Collaborators

• University of Missouri-Columbia: lead

Study Sites (1)

University of Missouri Hospital and Clinics

Columbia, Missouri, 65212, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Tissue samples.

MeSH Terms

Conditions

Pathologic Processes

Condition Hierarchy (Ancestors)

Pathological Conditions, Signs and Symptoms

Study Officials

• Bruce Ramshaw, MD

  University of Missouri-Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 7, 2007
• First Posted: September 11, 2007
• Study Start: August 1, 2007
• Primary Completion: November 1, 2010
• Study Completion: November 1, 2010
• Last Updated: August 8, 2016

Record last verified: 2016-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)