Cryosurvival of Embryos From Dysmorphic Oocytes
1 other identifier
observational
N/A
1 country
1
Brief Summary
Various morphological abnormalities of human oocytes were reported to detrimentally affect embryo development. We observed development of frozen thawed embryos derived from oocytes with normal or abnormal morphological features to the blastocyst stage. Cytoplasmic abnormalities of the oocytes were found to negatively affect cryosurvival potential of the embryos.
Trial Health
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Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 24, 2007
CompletedFirst Posted
Study publicly available on registry
August 27, 2007
CompletedAugust 27, 2007
August 1, 2007
August 24, 2007
August 24, 2007
Conditions
Study Arms (12)
Normal
Embryos derived from morphologically normal MII oocytes
Irregular Shapes
Embryos derived from irregularly shaped oocytes.
Large PVS
Embryos derived from oocytes with large perivitelline space.
Dark Zona
Embryos derived from oocytes with dark zona pellucida
Dark cytoplasm
Embryos derived from oocytes with dark cytoplasm
Vacuolar cytoplasm
Embryos derived from oocytes with vacuolated cytoplasm
Central granulation
Embryos derived from oocytes with centrally granulated cytoplasm
Double extra
Embryos derived from oocytes with double extracytoplasmic abnormalities
Double combined
Embryos derived from oocytes with any combination of one extracytoplasmic and one cytoplasmic anomaly
Double cytoplasmic
Embryos derived from oocytes with any two cytoplasmic anomalies
Triple extra
Embryos derived from oocytes with triple extracytoplasmic anomaly
Triple combined
Embryos derived from oocytes with triple combined anomalies
Interventions
Good quality human embryos were frozen - thawed and cultured to the blastocyst stage.
Eligibility Criteria
You may qualify if:
- Human embryos derived from morphologically normal or abnormal mature oocytes that fertilized normally by microinjection procedure.
- Embryos were obtained from couples who refused to freeze their supernumerary embryos after fresh embryo transfer in an assisted reproduction treatment cycle.
You may not qualify if:
- Embryos obtained after microinjection to immature oocytes taht were in vitro matured in culture.
- Embryos obtained from abnormally fertilized zygotes.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
VKV American Hospital
Istanbul, 34365, Turkey (Türkiye)
Related Publications (1)
Balaban B, Ata B, Isiklar A, Yakin K, Urman B. Severe cytoplasmic abnormalities of the oocyte decrease cryosurvival and subsequent embryonic development of cryopreserved embryos. Hum Reprod. 2008 Aug;23(8):1778-85. doi: 10.1093/humrep/den127. Epub 2008 May 12.
PMID: 18477573DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Basak Balaban, B.Sc.
Assisted Reproduction Unit of the VKV American Hospital of Istanbul
Study Design
- Study Type
- observational
- Observational Model
- DEFINED POPULATION
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
August 24, 2007
First Posted
August 27, 2007
Last Updated
August 27, 2007
Record last verified: 2007-08