Effects of Exercise Modality on Abdominal Obesity and Health Risk Factors in Older Men and Women
1 other identifier
interventional
145
1 country
1
Brief Summary
The prevalence of abdominal obesity in the elderly is increasing at alarming rates and thus, requires immediate attention. By comparison to younger adults, obesity reduction in the elderly presents a unique challenge and requires an innovative approach. We propose a novel approach to investigate the effects of different exercise types as independent treatment strategies for the reduction of obesity and related health risk factors in older men and women. We propose that exercise without caloric restriction will be associated with modest weight loss (3-5%), that in turn will be associated with significant reduction in abdominal obesity, insulin resistance, and a corresponding increase in skeletal muscle mass and function. We will determine the separate effects of resistance and aerobic exercise on these primary outcome variables, and, whether a treatment strategy that combines the two is optimal.
Trial Health
Trial Health Score
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participants targeted
Target at P75+ for not_applicable
1 active site
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2003
CompletedFirst Submitted
Initial submission to the registry
August 24, 2007
CompletedFirst Posted
Study publicly available on registry
August 27, 2007
CompletedApril 22, 2008
April 1, 2008
August 24, 2007
April 21, 2008
Conditions
Outcome Measures
Primary Outcomes (1)
Abdominal obesity
6 months
Secondary Outcomes (1)
Insulin Resistance
6 Months
Study Arms (4)
C
NO INTERVENTIONRE
ACTIVE COMPARATORResistance Exercise
AE
ACTIVE COMPARATORAerobic Exercise
RAE
ACTIVE COMPARATORResistance and Aerobic
Interventions
Eligibility Criteria
You may qualify if:
- Men and women between 65 and 80 years of age.
- Men and women are self-sufficient, sedentary, abdominally obese (BMI between 27 and 34.9 kg/m2; waist circumference greater than 88 cm in women and 102 cm in men), weight stable (± 2 kg) for 6 months prior to the beginning of the study, be non-smokers, and not diabetic.
- We will study elderly women who are not taking hormone replacement therapy to create a homogeneous population in whom the effect of exercise on the principal outcome variables can be evaluated with minimal confounding.
You may not qualify if:
- Smokers and diabetics.
- Women taking hormone replacement therapy.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Queen's Universitylead
- Canadian Institutes of Health Research (CIHR)collaborator
Study Sites (1)
Queen's University
Kingston, Ontario, K7L 3N6, Canada
Related Publications (1)
Davidson LE, Hudson R, Kilpatrick K, Kuk JL, McMillan K, Janiszewski PM, Lee S, Lam M, Ross R. Effects of exercise modality on insulin resistance and functional limitation in older adults: a randomized controlled trial. Arch Intern Med. 2009 Jan 26;169(2):122-31. doi: 10.1001/archinternmed.2008.558.
PMID: 19171808DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Robert Ross
Queen's University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
August 24, 2007
First Posted
August 27, 2007
Study Start
September 1, 2003
Last Updated
April 22, 2008
Record last verified: 2008-04