Synovial Fluid Bank From Arthritic Patients

NCT00512343 | Recruiting DMC

• 1 other identifier: 02-12 LS
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The objectives of this group project is to collect synovial fluid (SF) and paired sera and carry out preclinical studies to evaluate, alone or by combination testings, the potential of novel biomarkers for their prevalence and diagnostic/prognostic values in patients with arthritis, and to determine how therapeutic intervention regulate their levels.

Conditions

Arthritis

Keywords

Synovial Fluid; Arthritis; Paired serum/synovial fluid samples

Outcome Measures

Primary Outcomes (1)

• Availability of paired synovial fluid and serum samples for exploratory studies

  Availability of paired synovial fluid and serum samples, linked with anonymized clinical and treatment data, from patients suffering from various arthritides (rheumatoid arthritis, gout and other microcrystalline arthritides, osteoarthritis, spondylarthropathies, juvenile idiopathic arthritis, and various other diseases, including inflammatory polyarthritis of recent-onset in adults

  Use with various collaborators at different times, upon request and approbation

Eligibility Criteria

• Age: 3 Years - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients suffering from various arthritides (rheumatoid arthritis, gout and other microcristalline arthritides, osteoarthritis, spondylarthropathies, juvenile idiopathic arthritis, and various other diseases, including inflammatory polyarthritis of recent-onset in adults

You may qualify if:

• Significant joint effusion

You may not qualify if:

• Hemorrhagic effusion
• Traumatic effusion
• Less than 3 ml total of collected fluid (used for routine analysis and culture)
• Inability or refusal to consent

Sponsors & Collaborators

• Gilles Boire: lead
• Canadian Arthritis Network: collaborator

Study Sites (1)

Centre hospitalier universitaire de Sherbrooke

Sherbrooke, Quebec, J1H 5N4, Canada

RECRUITING

Related Publications (2)

• Kilani RT, Maksymowych WP, Aitken A, Boire G, St-Pierre Y, Li Y, Ghahary A. Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation. J Rheumatol. 2007 Aug;34(8):1650-7. Epub 2007 Jul 1.

  PMID: 17611984 RESULT

• Simard N, Boire G, de Brum-Fernandes AJ, St-Pierre Y. A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis. Arthritis Res Ther. 2006;8(4):R125. doi: 10.1186/ar2014.

  PMID: 16859524 RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

Synovial fluids from joints with effusion Sereum samples drawn on the same day

MeSH Terms

Conditions

Arthritis

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Study Officials

• Gilles Boire, MD, MSc

  CHUS and Université de Sherbrooke

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Gilles Boire, MD, MSc

CONTACT

(819) 564-5261; Gilles.Boire@USherbrooke.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: August 3, 2007
• First Posted: August 7, 2007
• Study Start: June 1, 2002
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): September 1, 2030
• Last Updated: March 25, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)