NCT00505011

Brief Summary

Cigarette smoking is a well-recognized risk factor of Graves' disease and, particularly, Graves' ophthalmopathy. Hence, germline polymorphisms of detoxification genes and genes belonging to the major DNA repair/apoptosis pathways might have an important role in disease susceptibility. In addition, as some of these genes are regulated by thyroid hormones, they could affect the outcome of these patients. Our objective was to assess the influence of the GST, CYP and TP53 gene polymorphisms in the risk of Graves' disease and its outcome.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,998

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 1998

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 1998

Completed
9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2007

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

July 18, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 20, 2007

Completed
Last Updated

July 20, 2007

Status Verified

July 1, 2007

First QC Date

July 18, 2007

Last Update Submit

July 19, 2007

Conditions

Graves' Disease

Keywords

susceptibilitygenesenvironmentophthalmopathyoutcome

Eligibility Criteria

Age2 Years+
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Graves' disease patients

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Graves DiseaseDisease SusceptibilityEye Diseases

Condition Hierarchy (Ancestors)

ExophthalmosOrbital DiseasesGoiterThyroid DiseasesEndocrine System DiseasesHyperthyroidismAutoimmune DiseasesImmune System DiseasesDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Laura S Ward, MD, PhD

    State University of Campinas- UNICAMP

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
OTHER
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 18, 2007

First Posted

July 20, 2007

Study Start

February 1, 1998

Study Completion

February 1, 2007

Last Updated

July 20, 2007

Record last verified: 2007-07