NCT00494923

Brief Summary

The Erlangen Glaucoma Registry is a clinical registry for cross sectional and longitudinal observation of patients with open angle glaucoma (OAG) or glaucoma suspect, founded in 1991. The primary aim is the evaluation of diagnostic and prognostic validity of morphometrical, sensory and hemodynamical diagnostic procedures. No therapeutic studies are performed.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
2,500

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 1999

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 1999

Completed
8.5 years until next milestone

First Submitted

Initial submission to the registry

June 29, 2007

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 2, 2007

Completed
8.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2015

Completed
5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2020

Completed
Last Updated

December 12, 2013

Status Verified

December 1, 2013

Enrollment Period

16.9 years

First QC Date

June 29, 2007

Last Update Submit

December 11, 2013

Conditions

Primary Open Angle GlaucomaSecondary Open Angle GlaucomaOcular Hypertension

Outcome Measures

Primary Outcomes (1)

  • Time to Disease Progression

    up to 20 years

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

primary care clinic

You may qualify if:

  • Open anterior chamber angle
  • Best corrected visual acuity 0.7 or better
  • Age between 18 and 65 years

You may not qualify if:

  • Any eye disease other than glaucoma
  • Systemic diseases with potentially ocular involvement (e.g., diabetes mellitus)
  • Myopic or hyperopic refractive error exceeding 8.0 diopters

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Eye Hospital

Erlangen, 91054, Germany

RECRUITING

Related Publications (28)

  • Wessel JM, Horn FK, Tornow RP, Schmid M, Mardin CY, Kruse FE, Juenemann AG, Laemmer R. Longitudinal analysis of progression in glaucoma using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3613-20. doi: 10.1167/iovs.12-9786.

    PMID: 23633657RESULT

  • Hoesl LM, Tornow RP, Schrems WA, Horn FK, Mardin CY, Kruse FE, Juenemann AG, Laemmer R. Glaucoma diagnostic performance of GDxVCC and spectralis OCT on eyes with atypical retardation pattern. J Glaucoma. 2013 Apr-May;22(4):317-24. doi: 10.1097/IJG.0b013e318237c8c5.

    PMID: 22027931RESULT

  • Schrems WA, Laemmer R, Hoesl LM, Horn FK, Mardin CY, Kruse FE, Tornow RP. Influence of atypical retardation pattern on the peripapillary retinal nerve fibre distribution assessed by scanning laser polarimetry and optical coherence tomography. Br J Ophthalmol. 2011 Oct;95(10):1437-41. doi: 10.1136/bjo.2010.190074. Epub 2011 Jan 17.

    PMID: 21242583RESULT

  • Hoesl LM, Mardin CY, Horn FK, Juenemann AG, Laemmer R. Influence of glaucomatous damage and optic disc size on glaucoma detection by scanning laser tomography. J Glaucoma. 2009 Jun-Jul;18(5):385-9. doi: 10.1097/IJG.0b013e3181845ffd.

    PMID: 19525729RESULT

  • Schrems WA, Mardin CY, Horn FK, Juenemann AG, Laemmer R. Comparison of scanning laser polarimetry and optical coherence tomography in quantitative retinal nerve fiber assessment. J Glaucoma. 2010 Feb;19(2):83-94. doi: 10.1097/IJG.0b013e3181a2fc0e.

    PMID: 19373100RESULT

  • Horn FK, Mardin CY, Laemmer R, Baleanu D, Juenemann AM, Kruse FE, Tornow RP. Correlation between local glaucomatous visual field defects and loss of nerve fiber layer thickness measured with polarimetry and spectral domain OCT. Invest Ophthalmol Vis Sci. 2009 May;50(5):1971-7. doi: 10.1167/iovs.08-2405. Epub 2009 Jan 17.

    PMID: 19151389RESULT

  • Laemmer R, Schroeder S, Martus P, Viestenz A, Mardin CY. Quantification of neuroretinal rim loss using digital planimetry in long-term follow-up of normals and patients with ocular hypertension. J Glaucoma. 2007 Aug;16(5):430-6. doi: 10.1097/IJG.0b013e31804a5e80.

    PMID: 17700284RESULT

  • Laemmer R, Horn FK, Viestenz A, Juenemann AG, Mardin CY. Influence of optic disc size on parameters of retinal nerve fiber analysis with laser scanning polarimetry. Graefes Arch Clin Exp Ophthalmol. 2006 May;244(5):603-8. doi: 10.1007/s00417-005-0125-1. Epub 2005 Sep 21.

    PMID: 16175374RESULT

  • Tornow RP, Schrems WA, Bendschneider D, Horn FK, Mayer M, Mardin CY, Lammer R. Atypical retardation patterns in scanning laser polarimetry are associated with low peripapillary choroidal thickness. Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7523-8. doi: 10.1167/iovs.11-7557.

    PMID: 21862653RESULT

  • Horn FK, Lammer R, Mardin CY, Junemann AG, Michelson G, Lausen B, Adler W. Combined evaluation of frequency doubling technology perimetry and scanning laser ophthalmoscopy for glaucoma detection using automated classification. J Glaucoma. 2012 Jan;21(1):27-34. doi: 10.1097/IJG.0b013e3182027766.

    PMID: 21173705RESULT

  • Pasutto F, Krumbiegel M, Mardin CY, Paoli D, Lammer R, Weber BH, Kruse FE, Schlotzer-Schrehardt U, Reis A. Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1459-63. doi: 10.1167/iovs.07-1449.

    PMID: 18385063RESULT

  • Crux K, Huchzermeyer C, Kremers J, Horn FK. Objective detection of visual field defects with multifrequency VEPs. Doc Ophthalmol. 2024 Feb;148(1):15-24. doi: 10.1007/s10633-023-09949-4. Epub 2023 Sep 26.

    PMID: 37749441DERIVED

  • Dussan Molinos L, Huchzermeyer C, Lammer R, Kremers J, Horn FK. Blue-Yellow VEP with Projector-Stimulation in Glaucoma. Graefes Arch Clin Exp Ophthalmol. 2022 Apr;260(4):1171-1181. doi: 10.1007/s00417-021-05473-w. Epub 2021 Nov 25.

    PMID: 34821990DERIVED

  • Thiermeier N, Lammer R, Mardin C, Hohberger B. Erlanger Glaucoma Registry: Effect of a Long-Term Therapy with Statins and Acetyl Salicylic Acid on Glaucoma Conversion and Progression. Biology (Basel). 2021 Jun 16;10(6):538. doi: 10.3390/biology10060538.

    PMID: 34208432DERIVED

  • Denkel L, Hohberger B, Lammer R. Influence of Mitomycin C on the Therapeutic Success of Stand-Alone Xen45 Gel Stents and Its Combination with Cataract Surgery in Open-Angle Glaucoma Patients. Klin Monbl Augenheilkd. 2021 Aug;238(8):861-867. doi: 10.1055/a-1384-1020. Epub 2021 May 17.

    PMID: 34000747DERIVED

  • Hohberger B, Lucio M, Schlick S, Wollborn A, Hosari S, Mardin C. OCT-angiography: Regional reduced macula microcirculation in ocular hypertensive and pre-perimetric glaucoma patients. PLoS One. 2021 Feb 11;16(2):e0246469. doi: 10.1371/journal.pone.0246469. eCollection 2021.

    PMID: 33571215DERIVED

  • Tornow RP, Kolar R, Odstrcilik J, Labounkova I, Horn F. Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head. Graefes Arch Clin Exp Ophthalmol. 2021 Feb;259(2):483-494. doi: 10.1007/s00417-020-04934-y. Epub 2020 Sep 22.

    PMID: 32960321DERIVED

  • Hohberger B, Kunze R, Wallukat G, Kara K, Mardin CY, Lammer R, Schlotzer-Schrehardt U, Hosari S, Horn F, Munoz L, Herrmann M. Autoantibodies Activating the beta2-Adrenergic Receptor Characterize Patients With Primary and Secondary Glaucoma. Front Immunol. 2019 Oct 1;10:2112. doi: 10.3389/fimmu.2019.02112. eCollection 2019.

    PMID: 31632387DERIVED

  • Edlinger FSM, Schrems-Hoesl LM, Mardin CY, Laemmer R, Kruse FE, Schrems WA. Structural changes of macular inner retinal layers in early normal-tension and high-tension glaucoma by spectral-domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2018 Jul;256(7):1245-1256. doi: 10.1007/s00417-018-3944-6. Epub 2018 Mar 9.

    PMID: 29523993DERIVED

  • Junemann A, Hohberger B, Rech J, Sheriff A, Fu Q, Schlotzer-Schrehardt U, Voll RE, Bartel S, Kalbacher H, Hoebeke J, Rejdak R, Horn F, Wallukat G, Kunze R, Herrmann M. Agonistic Autoantibodies to the beta2-Adrenergic Receptor Involved in the Pathogenesis of Open-Angle Glaucoma. Front Immunol. 2018 Feb 12;9:145. doi: 10.3389/fimmu.2018.00145. eCollection 2018.

    PMID: 29483909DERIVED

  • Schrems-Hoesl LM, Schrems WA, Laemmer R, Kruse FE, Mardin CY. Precision of Optic Nerve Head and Retinal Nerve Fiber Layer Parameter Measurements by Spectral-domain Optical Coherence Tomography. J Glaucoma. 2018 May;27(5):407-414. doi: 10.1097/IJG.0000000000000875.

    PMID: 29329141DERIVED

  • Diekmann T, Schrems-Hoesl LM, Mardin CY, Laemmer R, Horn FK, Kruse FE, Schrems WA. Predictive Factors for Visual Field Conversion: Comparison of Scanning Laser Polarimetry and Optical Coherence Tomography. J Glaucoma. 2018 Feb;27(2):157-163. doi: 10.1097/IJG.0000000000000833.

    PMID: 29194206DERIVED

  • Gmeiner JM, Schrems WA, Mardin CY, Laemmer R, Kruse FE, Schrems-Hoesl LM. Comparison of Bruch's Membrane Opening Minimum Rim Width and Peripapillary Retinal Nerve Fiber Layer Thickness in Early Glaucoma Assessment. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT575-84. doi: 10.1167/iovs.15-18906.

    PMID: 27547890DERIVED

  • Schrems-Hoesl LM, Schrems WA, Laemmer R, Horn FK, Juenemann AG, Kruse FE, Mardin CY. Confocal Laser Scanning Tomography to Predict Visual Field Conversion in Patients With Ocular Hypertension and Early Glaucoma. J Glaucoma. 2016 Apr;25(4):371-6. doi: 10.1097/IJG.0000000000000171.

    PMID: 25304282DERIVED

  • La Mancusa A, Horn FK, Kremers J, Huchzermeyer C, Rudolph M, Junemann A. Pattern electroretinograms during the cold pressor test in normals and glaucoma patients. Invest Ophthalmol Vis Sci. 2014 Apr 7;55(4):2173-9. doi: 10.1167/iovs.13-13392.

    PMID: 24576876DERIVED

  • Horn FK, Tornow RP, Junemann AG, Laemmer R, Kremers J. Perimetric measurements with flicker-defined form stimulation in comparison with conventional perimetry and retinal nerve fiber measurements. Invest Ophthalmol Vis Sci. 2014 Apr 11;55(4):2317-23. doi: 10.1167/iovs.13-12469.

    PMID: 24355823DERIVED

  • Horn FK, Kaltwasser C, Junemann AG, Kremers J, Tornow RP. Objective perimetry using a four-channel multifocal VEP system: correlation with conventional perimetry and thickness of the retinal nerve fibre layer. Br J Ophthalmol. 2012 Apr;96(4):554-9. doi: 10.1136/bjophthalmol-2011-300844. Epub 2011 Nov 24.

    PMID: 22116959DERIVED

  • Barboni MT, Pangeni G, Ventura DF, Horn F, Kremers J. Heterochromatic flicker electroretinograms reflecting luminance and cone opponent activity in glaucoma patients. Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6757-65. doi: 10.1167/iovs.11-7538.

    PMID: 21778269DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

whole blood

MeSH Terms

Conditions

Glaucoma, Open-AngleOcular Hypertension

Condition Hierarchy (Ancestors)

GlaucomaEye Diseases

Study Officials

  • Anselm G Juenemann, Prof.

    University Erlangen-Nuremberg

    STUDY CHAIR

Central Study Contacts

Anselm G Juenemann, Prof.

CONTACT

**49-9131-8533001anselm.juenemann@uk-erlangen.de

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 29, 2007

First Posted

July 2, 2007

Study Start

January 1, 1999

Primary Completion

December 1, 2015

Study Completion

December 1, 2020

Last Updated

December 12, 2013

Record last verified: 2013-12

Locations

DE(1)