Study of Mechanisms of Anovulation in Polycystic Ovary Syndrome

NCT00492882 | Completed

• 1 other identifier: CP03/102
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

We previously hypothesized that the excess of Anti-Mullerian Hormone (AMH) at the level of ovarian selectable follicles could be involved in the follicular arrest of Polycystic Ovary Syndrome (PCOS), mainly through inhibition of FSH effect on aromatase expression.In this study, we plan to investigate whether a drop in the serum AMH level would be concomitant to the appearance of a dominant follicle induced by administration of mild amounts of exogenous FSH in women with PCOS.

Conditions

Anovulation

Keywords

Polycystic Ovary Syndrome; Follicular Arrest; Anti-Mullerian Hormone; FSH

Interventions

usual administration of exogenous recombinant FSH DRUG

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• normal sperm analysis in the partners and normal hysterosalpingography in all patients
• PCOS defined by Rotterdam criteria
• resistance to clomiphene citrate, i.e. no ovulation at 150 mg/day or no pregnancy after 6 ovulatory cycles

You may not qualify if:

• on-going pregnancy
• age\<18 or \>40 yr.
• unability to understand the treatment protocol
• other medications
• any co-existent morbid condition contra-indicating a pregnancy

Sponsors & Collaborators

• University Hospital, Lille: lead
• Organon: collaborator

Study Sites (1)

Hôpital Jeanne de Flandre - C.H.R.U.

Lille, 59037, France

Location

Related Publications (3)

• Desforges-Bullet V, Gallo C, Lefebvre C, Pigny P, Dewailly D, Catteau-Jonard S. Increased anti-Mullerian hormone and decreased FSH levels in follicular fluid obtained in women with polycystic ovaries at the time of follicle puncture for in vitro fertilization. Fertil Steril. 2010 Jun;94(1):198-204. doi: 10.1016/j.fertnstert.2009.03.004. Epub 2009 Apr 9.

  PMID: 19361798 BACKGROUND

• Hamilton-Fairley D, Kiddy D, Watson H, Sagle M, Franks S. Low-dose gonadotrophin therapy for induction of ovulation in 100 women with polycystic ovary syndrome. Hum Reprod. 1991 Sep;6(8):1095-9. doi: 10.1093/oxfordjournals.humrep.a137491.

  PMID: 1806568 BACKGROUND

• Pigny P, Jonard S, Robert Y, Dewailly D. Serum anti-Mullerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 Mar;91(3):941-5. doi: 10.1210/jc.2005-2076. Epub 2005 Dec 20.

  PMID: 16368745 RESULT

MeSH Terms

Conditions

Anovulation; Polycystic Ovary Syndrome

Condition Hierarchy (Ancestors)

Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Gonadal Disorders; Endocrine System Diseases; Ovarian Cysts; Cysts; Neoplasms

Study Officials

• Didier R DEWAILLY, MD

  University Hospital of Lille

  STUDY CHAIR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 26, 2007
• First Posted: June 27, 2007
• Study Start: November 1, 2003
• Study Completion: January 1, 2007
• Last Updated: May 14, 2026

Record last verified: 2003-09

Locations

FR (1)