NCT00491465

Brief Summary

Randomized, controlled, open, comparative intervention study in two groups, each consisting of 25 children with type 1 diabetes that will undergo twelve weeks of exercise program (intensive arm) and twelve weeks of regular activity (non intensive arm) separated by four week of washout period. The study will be conducted in a crossover manner: one group starting with the intensive arm followed by the non intensive arm and vice versa. Blood glucose, HbA1C, Fructosamine, 3 days continuous glucose monitoring system (CGMS), total daily insulin dose, fasting lipid profile, body impedance and BMR will be measured. Self esteem and quality of life questionnaires will be filled.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
2,007

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jul 2007

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 25, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

June 26, 2007

Completed
5 days until next milestone

Study Start

First participant enrolled

July 1, 2007

Completed
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2009

Completed
Last Updated

June 26, 2007

Status Verified

June 1, 2007

First QC Date

June 25, 2007

Last Update Submit

June 25, 2007

Conditions

Keywords

Type 1 Diabetes, physical activity, pediatric, metabolic control

Outcome Measures

Primary Outcomes (2)

  • HbA1C

    0,3 monthes

  • fructosamine

    0,3 monthes

Secondary Outcomes (3)

  • Body composition & BMR

    0,3 monthes

  • Self esteem & QOL questionnaires

    o, 3 monthes

  • 3 days CGMS & SBGM profile

    0,3 monthes

Interventions

Eligibility Criteria

Age8 Years - 16 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Type I diabetic children
  • Tanner stage II-IV
  • Patients of the Schneider's national institute of childhood diabetes. Duration of diabetes
  • more than one year.
  • HbA1C between 8 and 12 at time 0.
  • Mandatory 4 daily self blood glucose measurements and daily recording of adverse events.
  • A signed informed consent of the parents and child.

You may not qualify if:

  • Additional chronic significant disease such as cardiac, liver, renal disease .
  • Children who exercise regularly more than 180 min per week.
  • Cardiac symptoms: history of chest pain , syncope , palpitations or dyspnea during exercise.
  • Eating disorders.
  • Participation in a study during the past month.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Schnider children's medical center

Petah Tikva, Israel

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 1Motor Activity

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesAutoimmune DiseasesImmune System DiseasesBehavior

Study Officials

  • Ravital Nimri, MD

    Rabin Medical Center

    PRINCIPAL INVESTIGATOR
  • Moshe Phillip, Prof

    Rabin Medical Center

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ravital Nimri, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
CROSSOVER
Sponsor Type
OTHER

Study Record Dates

First Submitted

June 25, 2007

First Posted

June 26, 2007

Study Start

July 1, 2007

Study Completion

July 1, 2009

Last Updated

June 26, 2007

Record last verified: 2007-06

Locations