NCT00489333

Brief Summary

The purpose of this study is to compare the effects of supplementation with ProAlgaZyme (a novel fermentation product of a freshwater algae ecosystem) vs. placebo on Metabolic Syndrome and indicators of cardiovascular health including: body weight and fat, blood lipids, inflammatory markers such as hsCRP, blood pressure and fasting blood glucose.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
52

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started May 2006

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2006

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2006

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

June 19, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 21, 2007

Completed
Last Updated

June 21, 2007

Status Verified

June 1, 2007

First QC Date

June 19, 2007

Last Update Submit

June 19, 2007

Conditions

Keywords

ProAlgaZymeMetabolic syndromeInflammationCardiovascularhsCRPLipidsAlgae

Outcome Measures

Primary Outcomes (4)

  • hsCRP

    10 weeks

  • Lipids (total cholesterol, triglycerides HDL-C, LDL-C)

    10 weeks

  • Anthropometric measurements (weight/BMI, % body fat, blood pressure)

    10 weeks

  • Fasting Blood Glucose

    10 weeks

Secondary Outcomes (4)

  • Insulin

    10 weeks

  • Interleukin-6 (IL-6)

    10 weeks

  • TNF-alpha

    10 weeks

  • RBC Sedimentation Rate

    10 weeks

Interventions

Eligibility Criteria

Age25 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Participants must meet 3 of the following criteria:
  • BMI ≥30 kg/m2
  • HDL Cholesterol of \<40
  • Triglycerides \>150 mg/dl
  • Fasting blood glucose \>100 mg/dl
  • Blood pressure \>130/85 mm Hg
  • Total Cholesterol of \>200 mg/dl
  • LDL Cholesterol of \>160 mg/dl
  • Interleukin 6 (IL-6) \>5pg/mL

You may not qualify if:

  • Morbidly obese: BMI \>40 kg/m2
  • Taking any cholesterol-lowering medications 30 days prior to the start of enrollment and during the course of the study.
  • Enrolled in another clinical study in the past 6 months.
  • Pregnant, actively infected, on medication that interfered with healing (for example, steroids), were inflicted with systemic disease such as AIDS, HIV, active hepatitis or active malignancy (clinical signs within the past 5 years), or suffered from diabetes mellitus requiring daily insulin management.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Laboratory of Nutrition and Nutritional Biochemistry (LNNB), Department of Biochemistry, University of Yaounde I

Yaoundé, Cameroon

Location

Related Publications (1)

  • Oben J, Enonchong E, Kuate D, Mbanya D, Thomas TC, Hildreth DJ, Ingolia TD, Tempesta MS. The effects of ProAlgaZyme novel algae infusion on metabolic syndrome and markers of cardiovascular health. Lipids Health Dis. 2007 Sep 5;6:20. doi: 10.1186/1476-511X-6-20.

MeSH Terms

Conditions

Metabolic SyndromeInflammation

Condition Hierarchy (Ancestors)

Insulin ResistanceHyperinsulinismGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Julius Oben, Ph.D.

    Laboratory of Nutrition and Nutritional Biochemistry (LNNB), Department of Biochemistry, University of Yaounde I, Yaounde, Cameroon

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

June 19, 2007

First Posted

June 21, 2007

Study Start

May 1, 2006

Study Completion

September 1, 2006

Last Updated

June 21, 2007

Record last verified: 2007-06

Locations