Emotional Processing and Memory Evaluation in Epilepsy Patients

NCT00486239 | Completed

• 1 other identifier: 08-06-06
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to assess the effects of temporal lobe epilepsy (TLE) on memory and emotional functioning. The study will evaluate the known lateralized neurological dysfunction(Right TLE versus Left TLE) on emotional verbal and visual memory function. Study data will assess the ability of participants with known lateralized neurological dysfunction (Right TLE versus Left TLE) to differentially perceive emotional stimuli. Another component of the study will evaluate possible changes in memory function for emotionally charged material following right or left temporal lobectomy for the treatment of medically intractable epilepsy. It is expected participants with known lateralized dysfunction will exhibit differential ability to discriminate emotional charged visual and verbal material.

Conditions

Epilepsy

Keywords

Epilepsy; memory; emotion

Outcome Measures

Primary Outcomes (1)

• Evaluate the effects of known lateralized neurological dysfunction (Right TLE versus Left TLE) on emotional memory function.

  1 year

Study Arms (3)

1

EXPERIMENTAL

Behavioral TLE 1A

Behavioral: TLE Arm 1; Behavioral: Emotion Memory Test

2

EXPERIMENTAL

TLE Arm II

Behavioral: Emotion Memory Testing

B

EXPERIMENTAL

Control Arm B

Behavioral: Emotion Memory Testing

Interventions

TLE Arm 1 BEHAVIORAL

Behavioral/cognitive testing

1

Emotion Memory Test BEHAVIORAL

Behavioral/cognitive Measure

1

Emotion Memory Testing BEHAVIORAL

Behavioral/cognitive testing

2

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Referred to neurological institute at University Hospitals Case Medical Center for care of seizures/epilepsy
• Referred to neuropsychology laboratory for evaluation
• Participants must complete the routine check-in of all patients and sign consent and HIPAA forms.
• Be, in the investigator's opinion, compliant, able to follow the investigator's instructions and visit the clinic on schedule, cooperative and reliable.
• Be aged 18-64 years old.
• Be able to provide documented informed consent.
• Have a confirmed diagnosis of right or left temporal lobe epilepsy (TLE), which is made independent of their pre-surgical neuropsychological evaluation. Neurological disease must be confirmed by one (or more) of the following: (a) MRI study of the head, (b) CT study of the head, (c) EEG study, (d) Video-EEG study, (e) PET study of the head, (f) Neurological and Psychiatric exam by a physician.

You may not qualify if:

• Referred from an attorney or their evaluation is part of a personal injury claim.
• Be intoxicated from alcohol or other illicit substance.
• Received Electroconvulsive (ECT) treatment within the last 21 days.
• Have an MMSE score of 25 or less
• Have undergone Deep Brain Stimulator (DBS) surgery

Sponsors & Collaborators

• University Hospitals Cleveland Medical Center: lead

Study Sites (1)

University Hospitals Case Medical Center

Cleveland, Ohio, 44106, United States

Location

MeSH Terms

Conditions

Epilepsy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Mike R Schoenberg, PhD

  University Hospitals Cleveland Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 13, 2007
• First Posted: June 14, 2007
• Study Start: October 1, 2006
• Primary Completion: March 1, 2010
• Study Completion: March 1, 2010
• Last Updated: May 18, 2022

Record last verified: 2022-05

Locations

US (1)